Non-intoxicating cannabis compound CBD seems to help the body cope with stress.
CBD is a non-psychoactive cannabinoid compound found in cannabis. CBD possesses several health benefits, including the ability to alleviate stress by:
- Regulating the stress response. CBD appears to influence regions of the brain associated with responding to stressful stimuli, resulting in benefits such as reduced anxiety.
Cannabidiol (CBD) is the most abundant cannabinoid in cannabis (Cannabis sativa) after tetrahydrocannabinol (THC). CBD is growing increasingly popular as a supplement because of its multiple health benefits, the most notable of which are:
- Alleviation of anxiety, depression, and stress
- Reduction of pain and inflammation
Unlike THC, CBD has no psychoactive effects, meaning that it does not cause any euphoric or mind-altering effects. Coupled with its medicinal properties, this has made CBD an attractive option for helping with a long list of conditions that includes depression and other mental and neurological disorders, multiple sclerosis, and arthritis.
As a stress reducer, CBD seems to function by supporting the body’s response to stress. More specifically, it appears to reduce defensive responses to stressful events or stimuli, which can include adverse effects such as raised heart rate, blood pressure, and anxiety. 1
How CBD May Help With Stress
Interacting with serotonin receptors
Research suggests that CBD’s stress, anxiety and depression-reducing effects are mainly tied to its activation of the serotonin 5-HT1A receptor, which plays a role in regulating defensive responses to stressful stimuli. 2
Stimulating adult neurogenesis
Multiple cell culture studies have demonstrated that CBD increases adult hippocampal neurogenesis, the primary way that an adult mammalian brain can grow new brain cells. The impairment of adult neurogenesis has been linked to the development of anxiety and depression.
CBD Uses & Benefits for Stress
Reduction of stress and anxiety are the most popular uses of CBD supplements. And although research on CBD’s health benefits has only just begun, animal and human study findings support its potential to ameliorate both of these concerns, especially in the context of anxiety disorders. 3 In addition, CBD is also used to help with related issues such as difficulty sleeping and chronic pain.
Animal studies demonstrate that CBD can:
- Help the body cope with stress, as exemplified by the reduction of blood pressure, heart rate, and anxiety in rats exposed to restraint stress 4
- Reduce stress, anxiety, and depression in mice and rats 5 6 7
Current clinical research suggests that CBD helps the body cope with stress, particularly highlighted by its ability to reduce anxiety.
This double-blind, randomized study examined the effects of CBD on anxiety. A total of 24 people with Social Anxiety Disorder (SAD) were given placebo or CBD (600 mg) 90 minutes before a simulated public speaking test (SPST). The CBD treatment significantly lowered anxiety, cognitive impairment, and overall discomfort during the test. In addition, the performance of the CBD group was noted to be similar to 12 healthy controls (HC) who also underwent the test.
- The researchers concluded that “The increase in anxiety induced by the SPST on subjects with SAD was reduced with the use of CBD, resulting in a similar response as the HC.”8
In this double-blind, placebo-controlled study, people with social anxiety disorder (SAD) were given placebo or CBD (400 mg) and were examined using brain imaging. Compared to placebo, CBD was found to significantly decrease subjective anxiety through affecting regions of the brain that process defensive responses to stressful stimuli.
- The researchers concluded that “CBD reduces anxiety in SAD and that this is related to its effects on activity in limbic and paralimbic brain areas.” 9
This early double-blind study tested whether CBD was capable of reducing the anxiety produced by tetrahydrocannabinol (THC), the main psychoactive compound in cannabis. Eight people received the following treatments in different order: 0.5 mg/kg THC, 1 mg/kg CBD, a mixture containing 0.5 mg/kg delta 9-THC and 1 mg/kg CBD, diazepam, a common anti-anxiety drug (10 mg), and placebo. CBD was found to counteract the anxiety produced by THC.
- The researchers concluded that “the effects of CBD, as opposed to those of delta 9-THC, might be involved in the antagonism of effects between the two cannabinoids.”10
Dosage for Stress
- Clinical studies have used CBD doses as high as 600 mg, but not enough research has been done to suggest a standard dose
- CBD supplements typically suggest 20 – 25 mg doses of CBD, taken as as CBD hemp oil or CBD extract capsules
- Most CBD products are made from hemp, meaning that they do not contain enough THC to cause any mind-altering effects
Supplements in Review Says
- CBD oil 20+ mg for stress.
CBD seems to be an effective option for dealing with stress and anxiety. CBD has rapidly grown in popularity as a way to reap the benefits of cannabis without the intoxicating effects, and for good reason – current research findings are supportive of its ability to combat anxiety and stress.
There is too little research to recommend a specific dose, so it’s best to start low. There is a notable disparity between the large doses used by research studies and the small doses recommended by most CBD supplements. As such, it’s best to start with a low dose of 20 – 25 mg and then assess the effects to see if the dose should be increased.
- Campos AC et al. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5; 367(1607): 3364–3378. ↩
- Zanelati TV et al. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol. 2010 Jan;159(1):122-8. ↩
- Blessing EM et al. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015 Oct;12(4):825-36. ↩
- Resstel LB et al. 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. Br J Pharmacol. 2009 Jan;156(1):181-8. ↩
- Guimarães FS et al. Antianxiety effect of cannabidiol in the elevated plus-maze. Psychopharmacology (Berl). 1990;100(4):558-9. ↩
- de Mello Schier AR et al. Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS Neurol Disord Drug Targets. 2014;13(6):953-60. ↩
- Campos AC et al. The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. Int J Neuropsychopharmacol. 2013 Jul;16(6):1407-19. ↩
- Bergamaschi MM et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 2011 May;36(6):1219-26. ↩
- Crippa JA et al. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol. 2011 Jan;25(1):121-30. ↩
- Zuardi AW et al. Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology (Berl). 1982;76(3):245-50. ↩