Animal Researchsection" id="reducing-inflammation">Reducing inflammationt;">Ancient Indian gum resin guggul may diminish joint inflammation.
Extremely popular in India, guggul is considered a natural remedy in traditional Ayurvedic medicine. It may be particularly useful in joint health by:
- Reducing inflammation. Guggul has demonstrated anti-inflammatory properties, which may support alleviating joint pain and swelling.
Guggul (Commiphora wightii), also known as guggulu, is a flowering shrub or small tree that is indigenous to northern Africa and central Asia. It is most commonly cultivated in northern India, where it has been used as both an incense and medicine for almost 3,000 years.
As a revered herbal treatment in Unani and Ayurvedic medicine, guggul has been used to combat such ailments as obesity, high cholesterol, infections, and liver dysfunction, as well as to promote overall well-being.
The herb contains more than 100 bioactive compounds in its leaves, stem, root, and fruit. Among them are high concentrations of quinic acid and myo-inositol, as well as the steroid guggulsterone. Guggul has recently been introduced as a joint health supplement because of its anti-inflammatory and antioxidant properties, which may be especially beneficial in joint recovery.1
How Guggul Might Help With Joint HealthReducing inflammation
Guggul has been shown to reduce inflammation by suppressing the activation of NF-kB — a major pro-inflammatory compound — by interfering with several of its primary activators — hydrogen peroxide and TNF-alpha.2 3 4
The high guggulsterone content in guggul has been found capable of lowering the presence of pro-inflammatory cytokines such as IL-1b, IL-2, and TNF-a.5 It has further been shown to lower cyclooxygenase-2 (COX2) mRNA levels by inhibiting its activation by TNFa.6
Guggul Benefits & Uses for Joint Healthhas demonstrated that guggul has anti-inflammatory properties, which may enable it to benefit joint health by combating various joint conditions: 7
Compared to many other joint supplements, the use of guggul for joint health is relatively new and is mostly dedicated to the task of alleviating joint pain, stiffness, swelling, and other symptoms associated with arthritis.
Animal research has displayed the capacity of guggul to:
- Impart significant anti-arthritic activity in rats, especially by reducing swelling9