Animal & Petri Dish Research>Time-tested herb black cumin appears to alleviate rheumatoid arthritis.
Black cumin is a plant whose oil is known for its healing properties. In the context of joint health it can help with rheumatoid arthritis (RA) through:
- Immunomodulatory and anti-inflammatory activity. Black cumin has been shown to reduce inflammation and autoimmune responses involved in RA.
- Antioxidant activity. Black cumin’s antioxidant components can reduce the oxidative stress implicated in RA.
Black cumin (Nigella sativa) is a flowering herb common throughout Asia Minor, Southern Europe, and North Africa. The seeds of black cumin have a long history of use in culinary, religious, and medicinal practices, having been utilized by traditional medicine in India, Turkey, Saudi Arabia, Egypt, and many other countries.
The oil found in black cumin seeds is said to help with numerous conditions, such as digestive and respiratory problems, headaches, bacterial infections, and skin and joint issues. These uses are backed by medical research suggesting a multitude of beneficial properties: 1
- Antiarthritic (rheumatoid arthritis in particular)
Because of these and other effects, black cumin is widely considered one of the most effective and evidence-backed herbal remedies.
How Black Cumin Might Help With Joint Health
The main active component of black cumin oil is thymoquinone, but it also contains other beneficial compounds such as dithymoquinone, linoleic acid, oleic acid, thymol, and carvacrol. The constituents of black cumin appear to support joint health through:<
Immunomodulatory and anti-inflammatory activity
Black cumin seed oil has been shown to have multiple beneficial effects that reduce the inflammation and autoimmunity that are central to rheumatoid arthritis (RA). Specific mechanisms include:
- Inhibition of the NF-kappaB pathway that is associated with inflammation and autoimmune disorders 2
- Regulating cytokine production, most notably lowering levels of pro-inflammatory cytokines such as TNF-alpha and boosting anti-inflammatory ones such as IL-10 3
- Reducing the number of inflammatory cells such as eosinophils that are associated with allergies and autoimmunity 4
This randomized, double-blind, placebo-controlled study examined the efficacy of black cumin in rheumatoid arthritis (RA). A total of 42 people with RA were assigned to take two placebo or black cumin oil capsules (500 mg each) daily for 8 weeks. Only the black cumin group experienced an increase in the anti-inflammatory cytokine IL-10, and reduction in two markers of oxidative stress – MDA and NO.
- The researchers concluded that “Nigella sativa could improve inflammation and reduce oxidative stress in patients with RA.”9
In this placebo-controlled study, 40 women with RA were given placebo capsules for a month, followed by another month of black cumin oil capsules (500 mg twice daily). They experienced a significant improvement in RA disease activity, number of swollen joints, and duration of morning stiffness.
- The researchers concluded that “Supplementation with Nigella sativa during DMARD [disease-modifying antirheumatic drug] therapy in RA may be considered an affordable potential adjuvant biological therapy.” 10
Supplements in Review Recommendation>
We recommend black cumin oil for rheumatoid arthritis. A long history of use and solid research evidence suggest that black cumin is effective at alleviating rheumatoid arthritis.
The most research-backed dose is 1000 mg. Although more research needs to be done before an official dosage recommendation, 1000 mg (taken as two 500 mg capsules daily) of black cumin oil is currently the most common dose used by successful studies.
- Ahmad A et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013 May; 3(5): 337–352. ↩
- Mohamed A et al. Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis. Biomed Sci Instrum. 2005;41:388-93. ↩
- El-Obeid A et al. Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomedicine. 2006 May;13(5):324-33. ↩
- Abbas AT et al. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Immunol. 2005;12(1):95-102. ↩
- Wruck CJ et al. Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis. 2011 May;70(5):844-50. ↩
- Tekeoglu I et al. Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models. Phytother Res. 2007 Sep;21(9):895-7. ↩
- Umar S et al. Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. Chem Biol Interact. 2012 Apr 15;197(1):40-6. ↩
- Budancamanak M et al. Protective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritis. Arch Toxicol. 2006 Nov;80(11):768-76. ↩
- Hadi V et al. Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Avicenna J Phytomed. 2016 Jan-Feb; 6(1): 34–43. ↩
- Gheita TA and Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012 Aug;26(8):1246-8. ↩