Animal Researche: 18pt;">Time-tested burdock root may have liver-protective properties, but human research is lacking.
Burdock is an herb used in traditional medicine. Burdock root has been suggested to help with liver health through:
- Antioxidant effects. Burdock contains antioxidant compounds that protect the liver from oxidative stress involved in liver disorders and damage.
Arctium lappa, commonly known as burdock, is a Eurasian flowering plant of the sunflower family. Burdock root (“Niubang”) has been used in China and other countries as a vegetable and medicine for over 3,000 years.
Traditionally, dried 1-year-old burdock root is used to treat sore throat, skin conditions such as rashes and boils, and for clearing toxins from the body. Research confirms that burdock has many beneficial properties, including: 1
- Antimicrobial & antiviral
Today, burdock supplements are used for acne, dry skin, and other common skin issues, as well as arthritis, colds, high blood pressure, diabetes, and liver disorders. In terms of liver health, animal research suggests that burdock extract protects the liver from various types of damage.
Although there is currently no human research on burdock’s liver effects, animal studies demonstrate that burdock has hepatoprotective properties that protect the liver from various types of damage and fibrosis, and reduce elevated liver enzymes. These effects suggest that burdock may have potential benefits for liver health, but human studies are needed.
Animal studies of Burdock (A. lappa) extract consistently demonstrate that it protects the liver from damage and improves levels of liver enzymes used to measure liver function.
This animal study examined the effects of burdock in type 2 diabetic mice. A total of 70 mice were divided into 7 groups, with two diabetic and two healthy mice groups received 200 or 300 mg/kg A. lappa root extract daily for 28 days. Diabetes caused a number of effects, including an increase in levels of AST, ALT, and ALP – liver enzymes used as a marker of liver injury. Burdock extract significantly decreased AST, ALT, and ALP levels with a dose-dependent effect in both diabetic and healthy mice, indicating a hepatoprotective (liver-protective) effect.
- The researchers concluded that “A. lappa root extract has hypoglycemic effect and this extract can ameliorate lipid profiles as well as hepatic enzyme levels in diabetic mice.” 4
This animal study looked at whether burdock could protect the liver against cadmium toxicity. Male rats were administered cadmium with or without A. lappa extract (300 mg/kg) for 7 or 56 days. The extract decreased levels of liver enzymes, but they remained elevated in the cadmium-only group. It also improved other measures of liver function such as liver cell nucleus density.
- The researchers concluded that “…liver function indicators showed that A. lappa protected the liver against cadmium toxicity damage.” 5
This animal study examined the hepatoprotective (liver-protective) effects of b urdock. Rats were given ethanol (alcohol) and carbon tetrachloride (CCL4) to mimic the development of liver fibrosis, and then treated with A. lappa extract (300 mg/kg) for 1 or 7 days. The extract improved various markers of liver function that were worsened by ethanol plus CCL4, such as oxidative stress and elevated liver enzyme levels.
- The researchers concluded that “…hepatotoxicity induced by ethanol and potentiated by CCl(4) could be alleviated with 1 and 7 days of A. lappa treatment.” 6
In this animal study, mice were injected with carbon tetrachloride (CCl4) or Paracetamol, a medicine that can cause liver damage in high doses. A. lappa extract suppressed the elevation of liver enzymes caused by these toxic compounds in a dose-dependent way and reduced the severity of liver damage.
- The researchers concluded that “…A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages…” 7
Dosage for Liver Health>
Supplements in Review Recommendation>
Burdock root may have some benefits for liver health. Because of the scarcity of human research, we cannot outright recommend burdock root for liver concerns. However, animal studies suggest that it may have liver-protective properties that can help with a wide range of liver disorders.
Stick to dosages suggested by supplements. Since there are no human studies, it is best to use burdock dosages recommended by individual supplements. Most supplements suggest dosages of 800-1000 mg.
- Chan YS et al. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011 Oct;19(5):245-54. ↩
- .Halina Cichoż-Lach and Agata Michalak. Oxidative stress as a crucial factor in liver diseases. World J Gastroenterol. 2014 Jul 7; 20(25): 8082–8091. ↩
- Lin CC et al. Anti-inflammatory and radical scavenge effects of Arctium lappa. Am J Chin Med. 1996;24(2):127-37. ↩
- Akram Ahangarpour et al. Antidiabetic, hypolipidemic and hepatoprotective effects of Arctium lappa root’s hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice. Avicenna J Phytomed. 2017 Mar-Apr; 7(2): 169–179. ↩
- de Souza Predes F et al. Hepatoprotective effect of Arctium lappa root extract on cadmium toxicity in adult Wistar rats. Biol Trace Elem Res. 2014 Aug;160(2):250-7. ↩
- Lin SC et al. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. J Biomed Sci. 2002 Sep-Oct;9(5):401-9. ↩
- Lin SC et al. Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. Am J Chin Med. 2000;28(2):163-73. ↩