Animal Researchfont-size: 18pt;">Non-intoxicating cannabis compound CBD may help with digestive issues such as nausea, IBS, and IBD.
CBD is one of the main beneficial compounds found in cannabis plants. CBD has been suggested to help with digestive health by:
- Protecting against IBD. Early research indicates that CBD can ward off IBD and improve its symptoms.
- Alleviating IBS and other common digestive concerns such as nausea and abdominal pain.
Cannabidiol (CBD) is one of over 60 cannabinoids – compounds responsible for the medicinal benefits of cannabis. CBD is the second-most abundant cannabinoid after tetrahydrocannabinol (THC).
Whereas THC is largely responsible for the marijuana high, CBD is completely non-intoxicating. Because of this, more and more people are using it to reap the health benefits of cannabis without the mind-altering effects.
CBD is taken for chronic pain, arthritis, anxiety, insomnia, epilepsy, and many other health issues. In addition, some people are starting to supplement CBD to improve digestion and alleviate common digestive disorders such as IBD and IBS. These digestive system uses are supported by a growing volume of research.
How CBD Might Help With Digestive Health>More studies are needed to identify exactly how CBD improves digestion and alleviates gastrointestinal disorders. Potential research-backed mechanisms include:
Anti-inflammatory activity>Cannabidiol has been shown to have multiple effects that work together to reduce inflammation in the digestive tract, such as: 1
- Affecting levels of cytokines such as IL-1β and IL-10
- Counteracting the inflammatory effects of intestinal glial cells 2
- Reducing the effects of inducible nitric oxide synthase (iNOS), an enzyme that increases NO levels, which has been implicated in IBD
- Fighting oxidative stress involved in gut damage, such as that seen in inflammatory bowel disease (IBD)
Interacting with the endocannabinoid systemgure id="attachment_20795" style="width: 300px" class="wp-caption alignright">
THC resembles the structure of anandamide – an endocannabinoid that regulates pain, appetite, memory, and other processes. Image by NIDA(NIH) licensed under CC by 2.0
The body’s endocannabinoid system (ECS) plays a role in many bodily processes and systems, including digestion. For example, there is evidence that the ECS can affect intestinal inflammation, abdominal pain, and the link between the gut and the brain (gut-brain axis). 3 Some researchers have even gone so far as to propose that a deficiency in endocannabinoids (cannabinoids produced in the body) may be behind irritable bowel syndrome. 4
Although CBD does not strongly interact with the two known ECS (CB1 & CB2) receptors, it may interact with other undiscovered ECS receptors,5 and can indirectly affect the ECS by increasing levels of anadamide, a cannabinoid made in the human body. 6
CBD Uses & Benefits for Digestive HealthSome people use CBD to alleviate digestive symptoms such as nausea, digestive pain, and diarrhea, and to improve inflammatory bowel disease (ulcerative colitis and Crohn’s disease) and irritable bowel syndrome (IBS) – some of the most common digestive disorders worldwide.
There is a large amount of animal and cell culture research data supporting these uses. In particular, preclinical studies suggest that CBD is a “potential candidate for the development of a new class of anti-IBD drugs.” 7
But while this research is promising, there are few clinical studies of CBD’s digestive effects, making it difficult to say just how effective it is in humans.
Animal and isolated cell culture studies of CBD demonstrate beneficial effects on digestive issues. Specific findings indicate that CBD:
- Protects against colitis (a type of IBD) in rodents, with stronger effects when it is combined together with THC 8 9 10
- Suppresses nausea in animals 11
- Has anti-inflammatory effects in isolated, inflamed human colon tissue 12
Human Research href="https://www.ncbi.nlm.nih.gov/pubmed/29538683" target="_blank" rel="noopener">CBD-rich extract (100-500 mg) may improve inflammatory bowel disease
This randomized, double-blind, placebo-controlled pilot study examined the effects of CBD on inflammatory bowel disease. A total of 39 patients with ulcerative colitis (UC) were given CBD-rich cannabis extract (50 mg, containing 3.2-4.7% THC and small amounts of other cannabis compounds) or placebo capsules twice daily before meals for 2 weeks, and 250 mg twice daily for another 8 weeks. The CBD group experienced significant improvement of colitis activity scores, illness severity, and self-reported quality-of-life measures.
- The researchers concluded that “…several signals suggest CBD-rich botanical extract may be beneficial for symptomatic treatment of UC.” 13
Dosage for Digestive Health
Supplements in Review Recommendation
You can give CBD a try for digestive issues. Although it’s too early to say anything conclusive due to the scarcity of human studies, preclinical research suggests that CBD can help with IBD, IBS, and related digestive issues such as nausea and abdominal pain.
CBD capsules appear to be the best form. It seems that CBD capsules may be the best form for digestive issues, and they are the only form used in a human study. In terms of dose, it’s too early to tell what works best, so you should start with 15 mg and move up until you feel the desired effect.
- Izzo AA and Sharkey KA. Cannabinoids and the gut: new developments and emerging concepts. Pharmacol Ther. 2010 Apr;126(1):21-38. ↩
- De Filippis D et al. Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. PLoS One. 2011;6(12):e28159. ↩
- Sharkey KA, Wiley JW. The Role of the Endocannabinoid System in the Brain-Gut Axis. Gastroenterology. 2016 Aug;151(2):252-66. ↩
- Russo EB. Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuro Endocrinol Lett. 2008 Apr;29(2):192-200. ↩
- Schuelert N and McDougall JJ. The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. Neurosci Lett. 2011 Aug 1;500(1):72-6. ↩
- Deutsch DG. A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs). Front Pharmacol. 2016 Oct 13;7:370. eCollection 2016. ↩
- Esposito G et al. Cannabidiol in inflammatory bowel diseases: a brief overview. Phytother Res. 2013 May;27(5):633-6. ↩
- Borrelli F et al. Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis. J Mol Med (Berl). 2009 Nov;87(11):1111-21. ↩
- Jamontt JM et al. The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. Br J Pharmacol. 2010 Jun;160(3):712-23. ↩
- Regina M. Krohn et al. Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment. Journal of Inflammation 2016 13:21. ↩
- Parker LA et al. Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting. Physiol Behav. 2006 Jan 30;87(1):66-71. Epub 2005 Sep 28. ↩
- Couch DG et al. Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon. Clin Sci (Lond). 2017 Oct 25;131(21):2611-2626. ↩
- Irving PM et al. A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis. Inflamm Bowel Dis. 2018 Mar 19;24(4):714-724. ↩