Early research indicates that supplementing the sugar ribose may increase energy levels in people suffering from chronic fatigue.

• Supporting ATP production. Ribose is believed to boost energy in people with chronic fatigue through increasing production of ATP.

Overview

Ribose, also known as D-ribose (its natural form) is a sugar compound naturally produced from glucose in the body. Ribose is crucial to proper energy metabolism through its involvement in the synthesis of RNA, DNA, and most importantly adenosine triphosphate (ATP) – the main cellular energy source.

Ribose supplements are sometimes used by bodybuilders and athletes looking to enhance exercise performance by increasing the availability of ATP in muscle tissue. Despite this, the vast majority of clinical research studies suggest that ribose does not enhance exercise performance in healthy individuals.

On the other hand, supplementing ribose in people suffering from prolonged fatigue – and particularly those with chronic fatigue syndrome (CFS) and fibromyalgia (FMS) – seems to hold some value. Early research indicates that in these cases, ribose can substantially increase energy levels and related parameters such as mood and mental clarity.

How Ribose Might Help With Energy

Supporting ATP production

ATP is the main energy source of all organisms. However, ATP production can be impaired in some cases, such as the mitochondrial dysfunction implicated in chronic fatigue syndrome. Because ribose is directly involved in ATP production, it can help the body restore ATP and thus reduce fatigue and increase energy levels.

Ribose Potential Uses and Benefits for Energy

Ribose is widely used as an energy booster by people who suffer from prolonged or chronic fatigue, such as older adults, and particularly people with chronic fatigue syndrome and fibromyalgia. Early research seems to indicate that in these cases, ribose can enhance energy levels by helping support healthy ATP levels.

This would also explain why similar to other supplements that are involved in ATP production – such as ALA and CoQ10 – ribose offers no energy-related benefits for healthy individuals, whose ATP levels are already healthy.

Research

Human Research

Early clinical research indicates that ribose can substantially (45 – 61%) enhance energy levels in people with prolonged fatigue and CFS/FMS in particular.

Ribose (15g) may increase energy levels in people with chronic fatigue syndrome and fibromylagia

This preliminary study examined ribose supplementation in people with chronic fatigue syndrome (CFS) and fibromylagia (FMS). A total of 41 people with CFS and/or FMS were given D-ribose (5 g three times daily) for 17-35 days. They reported an average 45% improvement in energy levels and a 30% improvement in overall well-being.

• The researchers concluded that “D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome.”¹

Ribose (15 g) appears to increase energy levels in CFS/FMS patients

In this follow-up study, 203 people with CFS or FMS were given D-ribose (5 g three times daily) for 3 weeks. The supplementation resulted in an average 61.3% increase in energy levels and 37% improvement in overall well-being.

• The researchers concluded that “D-ribose resulted in markedly improved energy levels, sleep, mental clarity, pain relief, and well being in patients suffering from fibromyalgia and chronic fatigue syndrome.”²

Ribose (6 g) may increase energy levels in older adults complaining of fatigue

This study examined D-ribose supplementation for reducing fatigue in older adults. Ten participants aged 50 or older who complained of fatigue for at least 1 month were given D-ribose (6 g) daily for 2 weeks. Supplementation resulted in a notable improvement of subjective ratings of vitality and mental outlook, which was accompanied to by improvements aerobic fitness

• The researchers concluded that “D-Ribose may offer a nutritional energy enhancement benefit in improving symptomatology.“³

Dosage for Energy

• Research studies have successfully used ribose doses of 3 – 5 g, taken 2-3 times daily
• Ribose supplements typically come as a powder taken in 5 g servings

Available Forms

• Ribose is most commonly sold as a powder, but can also come in capsule and tablet forms