Animal Researchsection" id="promoting-anxiolytic-sedative-effects">Promoting Anxiolytic & Sedative Effects chamomile may soothe the body as it prepares for sleep.
Considered by some to be the Western counterpart to ginseng, chamomile has been in use since the days of ancient Egypt, Greece, and Rome. It has long been popular as a remedy for various medical complaints and may also be useful for sleep by:
- Promoting sedation. Chamomile is commonly regarded as a mild tranquilizer, especially for its apigenin content.
- Inducing sleep. The herb is reportedly useful for calming the body and helping deepen sleep.
- Diminishing anxiety. Modest anxiolytic activity has been spotted in chamomile users.
OverviewChamomile, or “earth apple” in its original Greek, is the common name for a collection of daisy-like plants. It is native to numerous countries throughout Europe, including Germany, France, Spain, and Italy, to list a few, which accounts for its widespread use. The popular herb holds several varieties under its wing. Each type is distinct and demands its particular conditions to flourish.
Two of the most prominent species are:
- German chamomile, Matricaria chamomilia. Referred to as the “water of youth,” the German version is most routinely employed in cases of inflammation, anxiety, and insomnia.
- Roman chamomile, Chamaemelum nobile. Sweet and crisp, Roman chamomile is believed to be a calming agent and sleeping aid.
Chamomile has been extensively used in Ayurvedic and Western medicine in a myriad of forms both internally and externally. Several of its principal applications are as an anti-inflammatory, an anti-allergenic, a relaxing sleep aid, a digestive, and a measure to combat symptoms of the everyday cold and fever.1
Primary restorative components drawn from its flowers include:
- Volatile oils (terpenoids). Bisabolol and bisabolol oxides A & B seem most impactful.
- Flavonoids. Apigenin appears to be the most active among the 36 flavonoids.
Recent and continuing research has pinpointed it’s calmative and anxiolytic properties as backing for its prospective as a relaxant and sleep aid.
How Chamomile May Hel
How Chamomile May Help With Sleep & Sedative Effects
Apigenin, one of the most abundant compounds isolated from chamomile, is believed to promote anxiolytic and muscle-relaxing effects due to its connection to benzodiazepine.2
Benzodiazepines are widely used in medical practices to diminish anxiety, muscle tension, and insomnia. One study found that apigenin was clearly capable of reducing anxiety at low doses and inducing mild sedation at much higher doses by assisting the binding of chemicals to benzodiazepine receptors and other similar GABAergic neurotransmission mechanisms.3
Beyond apigenin exist other similar compounds in chamomile extracts capable of binding to benzodiazepine and GABA receptors, which may contribute to its competence as a sedative, but few, if any, studies have confirmed their effectiveness.
Chamomile Benefits & Use
Chamomile Benefits & Uses for Sleep preparations have been used to manage insomnia through sedation, which involves a collection of calming, muscle-relaxing, and sleep inducing effects, thanks to apigenin.5
Tea and essential oil aromatherapy appear to be the most frequently consumed forms of chamomile, although inhalation of its oil vapors seemed to reduce adrenocorticotropic hormone (ACTH) levels, which generally increase as a consequence of stress.6
On top of minimizing stress hormones, chamomile may be an option that works for anxiety relief, particularly in cases of generalized anxiety disorders.7
Researchindicates that chamomile has potential as a sleep aid by:
- Relaxing the body. A slow, concentration-dependent relaxation was observed in pig blood vessels after applying a few chamomile compounds, such as apigenin and bisabolol.8
- Decreasing sleep latency. A significant decrease in sleep latency was noted in rats that ingested chamomile.9
- Reducing stress. Calves administered chamomile in their diet had significantly lower cortisol levels10
Human Researche limited number of clinical studies available, chamomile appears to reduce anxiety and promote sleep but does not quite achieve statistical significance. Farther studies are needed to verify chamomile’s true impact on sleep as well as the most effective dosage.
In this randomized, double-blind, placebo-controlled study, 34 adults with insomnia were given either 270 mg of chamomile or a placebo twice daily for 28 days. There were slight to modest improvements in sleep latency, night time awakenings, daytime functioning, and fatigue severity, but none of the results reached a level of statistical significance.
- The study concluded that “chamomile could provide modest benefits of daytime functioning and mixed benefits on sleep diary measures relative to placebo in adults with chronic primary insomnia.”11
In this randomized investigation, 80 postnatal Taiwanese women with poor sleep quality were given either chamomile tea or control care over the course of 2 weeks. Chamomile significantly lowered sleep inefficiency and the symptoms of depression on the short term.
- The study concluded that “chamomile tea may be recommended to postpartum women as a supplementary approach to alleviating depression and sleep quality problems.”12
In this randomized, double-blind, placebo-controlled investigation, 61 patients with mild generalized anxiety disorder (GAD) were given a chamomile extract or placebo for a period of 8 weeks. At the end of the study, there was a significantly greater reduction in average total Hamilton Anxiety Rating (HAM-A) scores for those who took chamomile.
- The study concluded that “chamomile may have modest anxiolytic activity in patients with mild to moderate GAD.”13
Dosage for Sleep
Dosage for Sleep
Most chamomile extracts are standardized to 1.2% apigenin.
Supplements in Review SaysSupplements in Review Says4pt;">Chamomile tea, 1 cup
Chamomile seems to promote sleep and relaxation. We recommend taking chamomile for its modest potential as a sleep aid. Although chamomile does seem to encourage sleep by calming the body, clinical studies concerning the flower are somewhat lacking. Probable sleep effects include improving sleep quality, reducing sleep latency, and decreasing insomnia. Additional health benefits may include stress relief and anxiety mitigation.
Take chamomile as a tea, 1 cup before bedtime. We suggest trying 1 cup of chamomile tea in the evening while research using extracts continues to advance and determine proper dosage. A prominent supplemental tablet from Planetary Herbals known as Chamomile Sleep® shows promise. The soothing evening drink should help to prepare the body and mind for rest and eventual sleep.
- Miraj S, Alesaeidi S. A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile). Electron Physician. 2016 Sep; 8(9): 3024-31. ↩
- Avallone R, Zanoli P, et al. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol. 2000 Jun 1;59(11):1387-94. ↩
- Viola H, Wasowski C, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med. 1995 Jun;61(3):213-6. ↩
- Gould L, Reddy CV, et al. Cardiac effects of chamomile tea. J Clin Pharmacol. 1973 Nov-Dec;13(11):475-9. ↩
- Avallone R, Zanoli P, et al. Benzodiazepine compounds and GABA in flower heads of matricaria chamomilla. Phytotherapy Res. 1996;10:177-9. ↩
- Paladini AC, Marder M, et al. Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds. J Pharm Pharmacol.1999;51:519-26. ↩
- Awad R, Levac D, et al. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Can J Physiol Pharmacol. 2007;85:933-42. ↩
- Roberts RE, Allen S, et al. Distinct mechanisms of relaxation to bioactive components from chamomile species in porcine isolated blood vessels. Toxicol Appl Pharmacol. 2013;272(3):797-805. ↩
- Shinomiya K, Inoue T, et al. Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats. Biol Pharm Bull. 2005 May;28(5):808-10. ↩
- Reis LS, Pardo PE, et al. Matricaria chamomilla CH12 decreases handling stress in Nelore calves. J Vet Sci. 2006 Jun;7(2):189-92. ↩
- Zick SM, Wright BD, et al. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011 Sep 22;11:78. ↩
- Chang SM, Chen CH. Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial. J Adv Nurs. 2016 Feb;72(2):306-15. ↩
- Amsterdam JD, Li Y, et al. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol. 2009 Aug;29(4):378-82. ↩
- Baumann LS. Less-known botanical cosmeceuticals. Dermatol Ther. 2007 Sep-Oct;20(5):330-42. ↩