Gynostemma pentaphyllum shows early indications of promoting fat loss in obese individuals.
Gynostemma pentaphyllum is an Asian vine that has been employed in herbal medical practices for centuries. Its leaves may help promote fat loss through:
- Activating AMPK. The activation of this enzyme has been associated with fat loss.
Gynostemma pentaphyllum is a climbing vine native to China, Vietnam, Korea, and Japan. It boasts a rich history as a health-promoting herb in traditional Chinese medicine, where it is known as jiaogulan, or “twisting indigo plant.”
Modern medicine has uncovered a number of health benefits stemming from the leaves of the plant. Its primary bioactive ingredients – ginsenosides, so called for being the active ingredients in Asian ginseng – are known to promote antioxidant1 and adaptogenic effects such as:
- Improving cardiovascular function2
- Diminishing high cholesterol and blood sugar
- Stabilizing blood pressure
Uniquely, Gynostemma is also full of gypenosides, which are substances that have demonstrated anti-diabetic properties, specifically in terms of balancing sugar and cholesterol levels characteristic of type II diabetes. It is these effects that have led to the claims that it can also promote weight loss.
How Gynostemma Pentaphyllum Might Help With Fat Loss
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- Increasing glucose uptake
- Increasing fat metabolism
- Reducing protein production
- Decreasing lipid (fat) synthesis
Gynostemma pentaphyllum was found to lessen obesity by significantly stimulating fat oxidation and glucose uptake through AMPK activation.5 6 Check out our fat burner guide for more details on fat oxidation.
Gynostemma Pentaphyllum Benefits & Uses for Fat Loss
Gynostemma pentaphyllum is popularly used as a weight loss supplement. More than simply a fat burner, it has also demonstrated potential in the treatment of medical conditions associated with excess fat, including:
But while there is plenty of evidence that G. pentaphyllum can help alleviate diabetes, its ability to promote fat loss is based on only a handful of studies. As such, it’s too early to say if it truly works as a weight loss pill.
Animal research indicates that Gynostemma pentaphyllum may be able to:
- Regulate lipid (fat) metabolism and cholesterol levels in rats with hyperlipidemia9 10
- Improve glucose tolerance in rats11 12
Early clinical research suggests that Gynostemma pentaphyllum may help fight obesity.
In this randomized, double-blind, placebo-controlled investigation, 80 obese Koreans were given either a placebo or Gynostemma pentaphyllum in the form of actiponin™ at 450 mg per day for 12 weeks. Compared to the placebo, actiponin™ supplementation led to significant decreases in weight, BMI, total abdominal fat area, body fat mass, and percent body fat.
- The researchers concluded that “actiponin supplementation may be effective for treating obese individuals.”13
In this randomized, single-blind investigation, 56 people with nonalcoholic fatty liver were given either a placebo a Gynostemma pentaphyllum extract capsule (80 ml) every day for 4 months. At the end of the study, significant reductions in body mass index (BMI) were reported in the Gynostemma pentaphyllum group.
- The researchers concluded that “GP is an effective adjunct treatment to diet therapy for patients with nonalcoholic fatty liver disease.”14
Dosage for Fat Loss
- Successful clinical research studies have use 450 mg of encapsulated Gynostemma pentaphyllum or 6 g of brewed whole leaves.
- Typical Gynostemma pentaphyllum supplements range from 1 – 2 g.
- 20:1 leaf extract in capsules or as a loose powder
- Dried whole leaf as a broth or tea
Supplements in Review Says
- Gynostemma pentaphyllum 450 mg for fat loss.
G. pentaphyllum shows potential for promoting fat loss. Although it’s too early to recommend, early research indicates that Gynostemma pentaphyllum can promote fat loss in obese individuals.
Start with 450 mg doses. We recommend taking 450 mg of Gynostemma powder or capsules, though it can also be taken in the form of leaves (6 g) steeped in hot water for tea.
- Lobo SN, et al. The Effect of Gynostemma pentaphyllum Extract on Mouse Dermal Fibroblasts. ISRN Dermatol. 2014 Mar 4;2014:202876. ↩
- Tanner MA, et al. The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum. Nitric Oxide. 1999 Oct;3(5):359-65. ↩
- Yang YF, et al. Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and α-glucosidase inhibitory activities. Food Chem. 2013 Dec 15;141(4):3606-13. ↩
- Kola B, et al. The role of AMP-activated protein kinase in obesity. Front Horm Res. 2008;36:198-211. ↩
- Guahar R, et al. Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase. Biotechnol Lett. 2012 Sep;34(9):1607-16. ↩
- Nguyen PH, et al. New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum. Bioorg Med Chem. 2011 Nov 1;19(21):6254-60. ↩
- Lokman EF, et al. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evid Based Complement Alternat Med. 2015;2015:120572. ↩
- Cheng JG, et al. Investigation of the plant jiaogulan and its analogous herb, Wulianmei. Zhong Cao Yao. 1990;21(9):424. ↩
- Yang YH, et al. Hypolipidemic effect of gypenosides in experimentally induced hypercholesterolemic rats. Lipids Health Dis. 2013 Oct 25;12:154. ↩
- Megalli S, et al. Phytopreventative anti-hyperlipidemic effects of gynostemma pentaphyllum in rats. J Pharm Pharm Sci. 2005 Sep 16;8(3):507-15. ↩
- Norberg A, et al. A Novel Insulin-releasing Substance, Phanoside, from the Plant Gynostemma pentaphyllum. The Journal of Biological Chemistry. 2004 Oct;279:41361-7. ↩
- Megalli S, et al. Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat. J Pharm Pharm Sci. 2006;9(3):281-91. ↩
- Park SH, et al. Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial. Obesity (Silver Spring). 2014 Jan;22(1):63-71. ↩
- Chou SC, et al. The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease. Altern Ther Health Med. 2006 May-Jun;12(3):34-9. ↩