Human Researchze: 18pt;">Collagen supplements may improve skin health and appearance by promoting collagen production, but more evidence is needed.
Collagen is a structural protein abundant in the skin and other connective tissue. Supplementing with collagen has been suggested to aid skin health by:
- Promoting collagen production. Collagen supplements may stimulate fibroblast cells in the skin to produce new collagen.
Collagen is a natural compound found in connective tissue. It is the most abundant protein in humans and other mammals, accounting for as much as 35% of all the protein in the body. As the main component of cartilage, skin, ligaments, tendons, bones, teeth, muscle, and other connective tissue, collagen helps hold the body together.
There are several kinds of collagen, but the three main ones are type I, II, and III. Whereas Type II collagen is found mainly in joint cartilage, types I and III are common in the skin, hair nails, and organs.
Collagen becomes depleted as we age, playing a role in the development of wrinkles, saggy skin, joint problems, and other connective tissue concerns. Because of this, collagen supplements, cosmetic products, and other treatments are growing increasingly popular as a way to restore the body’s collagen levels. It can be used both orally and topically, including capsules, powders, creams, dressings, and fillers.<
Do Collagen Supplements Work?
The major concern with collagen supplementation is whether collagen can get into the body. In the case of topical application, health experts suggest that collagen molecules are too large to be absorbed through the skin.
Meanwhile for oral supplements, the collagen peptides (amino acid chains) may be broken down into individual amino acids before they are absorbed into the blood. If this is the case, then taking collagen would be the same as taking a protein supplement (and far more expensive).
Fortunately, several animal and human studies have reported detectable collagen peptide levels in the blood after collagen supplementation, suggesting that at least some of these peptides remain intact after digestion. 1
How Collagen Might Help With Skin Health
Researchers are not entirely sure how collagen supplements might improve skin health, but the most popular hypothesis is:<
Stimulating collagen production
Fibroblasts are cells found in connective tissue that produce collagen and other structural support molecules that help maintain the shape and form of tissues. Assuming that oral collagen peptides are able to reach the intestine without being broken down and are absorbed into the bloodstream, they may work by stimulating skin fibroblasts to produce their own collagen. 2
There has not been much research on the effects of topical collagen preparations because it is widely accepted that collagen molecules are too large to be absorbed into the skin. In contrast, the last decade has seen an increasing number of studies on the effects of oral collagen peptide supplements. These studies report improvements in skin hydration, elasticity, collagen content, and other measures.
Despite these positive results, researchers stress the need for stronger evidence before we know for certain that oral collagen supplements are effective.
Read more: Skin Supplements Guide
Human studies of oral collagen hydrolysate supplementation report improvements in skin elasticity, hydration, wrinkles, collagen content, and other measures.
This randomized, double-blind, placebo-controlled study evaluate the skin aging benefits of an oral collagen hydrolysate (CH) supplement. A total of 69 women (age 35-55) took placebo, 2.5 g, or 5 g CH daily for 8 weeks, and had their skin health examined before and after supplementation. Both CH groups experienced significant improvements in skin elasticity, but not in other measures.
- The researchers concluded that “…skin elasticity in both CH dosage groups showed a statistically significant improvement in comparison to placebo.” 3
This randomized, controlled study examined the effects of an oral collagen peptide (CP) supplement on skin health. A total of 32 people were divided into 4 groups for 12 weeks: no supplement, CP (3 g), Vitamin C (500 mg), or CP plus vitamin C daily. Compared to placebo, both collagen groups improved in skin hydration (measured by corneometer) and elasticity (measured by cutometer).
- The researchers concluded that “Daily CP supplementation may improve skin hydration and elasticity.” 4
This randomized, double-blind, placebo-controlled study examined the effects of oral collagen hydrolysate supplements on skin health. A total of 80 women (age 35-55) took placebo, or one of two collagen preparations (5 g) daily for 8 weeks. Both collagen groups showed improvements in skin moisture, elasticity, wrinkles, and roughness. The collagen preparation with higher concentration of collagen peptides had better results.
- The researchers concluded that “…collagen hydrolysate with a higher content of Pro-Hyp and Hyp-Gly led to more improvement in facial skin conditions…” 5
This article described the results of two randomized, double-blind, placebo-controlled studies looking at the effects of oral collagen peptide supplementation. The studies included 33 and 106 women (aged 40-65), respectively, who were given placebo or branded collagen supplement Peptan (10 g) daily for 8 weeks. Both studies reported improvements in skin hydration, as well as collagen density and collagen network fragmentation – two additional measures of skin health.
- The researchers concluded that “The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging.” 6
This study examined the effects of multi-ingredient liquid collagen supplement Pure Gold Collagen on skin health and appearance. A total of 294 people drank the supplement in three different experimental groups: before a cosmetic procedure (e.g. chemical peel) for a total of 60 days; for 12 weeks; and for 18.5 weeks. The first group experienced reduced skin dryness, wrinkles, and nasolabial fold depth (laugh lines), the second group had increased skin collagen density, and the third group improved in skin firmness.
- The researchers concluded that “The data from this study suggest that Pure Gold Collagen can counteract signs of natural aging.” 7
Dosage for Skinl>
li>Collagen hydrolysate, 5-10 g for skin health.
Supplements in Review Recommendation
We recommend trying collagen hydrolysate for skin health. Although more research is needed to confirm that collagen remains active when taken orally, the available studies do point to multiple skin benefits.
Look for type I & III hydrolyzed collagen. This form and type of collagen has the most research evidence for improving skin health and appearance, when taken at dosage of 5 grams or more.
- Zague V. A new view concerning the effects of collagen hydrolysate intake on skin properties. Arch Dermatol Res. 2008 Oct;300(9):479-83. ↩
- Matsuda N et al. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo). 2006 Jun;52(3):211-5. ↩
- Proksch E et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. ↩
- Choi SY et al. Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study. J Cosmet Laser Ther. 2014 Jun;16(3):132-7. ↩
- Inoue N et al. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J Sci Food Agric. 2016 Sep;96(12):4077-81. ↩
- Asserin J et al. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015 Dec;14(4):291-301. ↩
- Maryam Borumand and Sara Sibilla. Daily consumption of the collagen supplement Pure Gold Collagen® reduces visible signs of aging. Clin Interv Aging. 2014; 9: 1747–1758. ↩