Human Research-section" id="blocking-the-conversion-of-t-into-dht">Blocking the conversion of T into DHTpalmetto may boost testosterone by blocking its conversion into dihydrotestosterone.
Saw palmetto is a fruit-bearing palm tree whose bioactive ingredients are believed to influence the conversion of sexual hormones. It may particularly affect masculinity by:
- Increasing testosterone levels. Saw palmetto may boost testosterone (T) by preventing it from converting into dihydrotestosterone (DHT).
- Improving sexual function. One of saw palmetto’s debatable benefits is improvement of sexual function.
The miniature palm tree, saw palmetto (Serenoa repens), is a tough, long-living plant that commonly grows in dense thickets as undergrowth in pine woods or along sandy coasts. It is native to the Southeastern United States and is especially prominent along Florida shorelines.
For centuries, saw palmetto has been incorporated into traditional herbal medical practices for its rumored health benefits: Mayans took it as a tonic, while Native Americans used it to treat sexual problems and infections.
Contemporary medical research has discovered that saw palmetto may be capable of increasing testosterone levels by reducing its conversion into dihydrotestosterone (DHT), a commonly misunderstood male hormone.1 This effect might also have implications for urinary and sexual health, and saw palmetto has been used as a diuretic and an aphrodisiac (to boost sexual drive), although the true extent of its benefits is still under debate.
Testosterone is converted into DHT through the action of the enzyme 5α-reductase.
Saw Palmetto Benefits & Uses for Testosteronehe various benefits of saw palmetto are tied to its potential knack for raising T and reducing DHT. Saw palmetto is specifically purported to:
Saw palmetto has also occasionally been used as an aphrodisiac and to enhance male virility, despite a lack of scientific backing.
Numerous clinical studies have verified the inhibitory impact of saw palmetto on 5-α-reductase, which in turn may increase T levels and reduce DHT levels.
In this investigation, 42 males were given a trademarked saw palmetto extract known as Alphastat® at either 800 milligrams (mg) or 2000 mg per day for a period of 14 days. Data analysis found significant increases in total testosterone levels and decreases in DHT and estrogen in both dosage groups.
- The study concluded that “both dose groups showed significant (p = 0.05) increases in T and decreases in DHT within three days of treatment with Alphastat.”9
In this randomized, placebo-controlled investigation, 20 males were given a placebo or a natural supplement containing astaxanthin and saw palmetto known as Resettin® at either 800 mg or 1200 mg every day for 14 days. DHT levels were significantly lowered in both dosage groups compared to the placebo. Moreover, the 1200 mg group was found to have reduced estrogen levels along with a 38% increase in testosterone levels.
- The study concluded that “Resettin® can favorably influence serum hormone profiles in men.”10
In this randomized, placebo-controlled investigation, 32 males were given either 5 milligrams of a 5-alpha-reductase inhibitor, finasteride, once a day or 80 mg of a saw palmetto extract known as Permixon® twice a day for 7 days. Unlike finasteride, Permixon® was not found to reduce DHT levels. Both treatments were shown to slightly elevate testosterone levels without extending beyond the normal range.
- The researchers concluded that “no significant difference was detected between finasteride and Permixon or between finasteride and placebo with respect to serum testosterone, except on days 3 and 6, respectively.”11
In this pilot investigation, 82 elderly men with sexual dysfunctions (SDys) and symptoms of BPH took one capsule containing 320 mg of a saw palmetto berry preparation, Prostasan®, every day for 8 weeks. By the end of the trial, the average prostate symptom score dropped from 14.4 ± 4.7 to 6.9 ± 5.2, whereas sexual function significantly improved based on both the Sexual Function Inventory (from 22.4 ± 7.2 to 31.4 ± 9.2) and the Urolife BPH QoL-9 sex total (from 137.3 ± 47.9 to 195.0 ± 56.3).
- The researchers concluded that “this was the first trial with saw palmetto to show improvement in BPH symptoms and SDys as well.”12
In this randomized, double-blind, placebo-controlled investigation conducted at 11 different clinical sites in North America, 369 males over 45 years of age or older were given 1, 2, and then 3 doses of either a placebo or 320 mg of saw palmetto daily for 72 weeks. No significant differences were noted in urinary or sexual function in any of the groups, though erectile and ejaculatory dysfunction slightly decreased in the saw palmetto group.
- The researchers concluded that “increasing doses of a saw palmetto fruit extract did not reduce lower urinary tract symptoms more than placebo.”13
In this review, 18 randomized and controlled investigations involving 2939 males with varying inclusion criteria were compared and analyzed. Compared to placebo, participants treated with saw palmetto (S. repens) had decreased urinary tract symptom scores, nocturia, and improvement in self-rating of urinary tract symptoms. Saw palmetto supplements resulted in similar improvements in urinary tract symptom scores and peak urine flow to finasteride.
- The researchers concluded that “S repens improves urologic symptoms and flow measures.”14
Dosage for Testosterone
- Successful clinical studies have used
Dosage for Testosteronetto, often standardized to 80 – 90% liposterolic compounds.
- Typical supplemental capsules range from 320 – 585 mg of powdered saw palmetto combined with 25% aqueous extract.
- Tablets or capsules
- Aqueous or liquid extra
Available Formsused as tea
- Ground, dried, or whole berry
Supplements in Review Says
- Supplements in Review Saysr testosterone.
Saw palmetto seems to have minor T boosting potential. Although more research is needed, current findings seem to suggest that saw palmetto may slightly increase testosterone levels. However, it does so at the expense of DHT, which despite its vilification still plays an important role in male health.
Take saw palmetto supplements at 160 – 320 mg per day. The best bet for saw palmetto supplementation appears to be a daily 160 – 320 mg dose in any one of its dried forms.
- Gordon AE, et al. Saw palmetto for prostate disorders. Am Fam Physician. 2003 Mar 15;67(6):1281-3. ↩
- Opoku-Acheampong AB, et al. Effect of Saw Palmetto Supplements on Androgen-Sensitive LNCaP Human Prostate Cancer Cell Number and Syrian Hamster Flank Organ Growth. Evid Based Complement Alternat Med. 2016;2016:8135135. ↩
- Bartsch G, et al. Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol. 2002 Apr;19(6):413-25. ↩
- Habib FK, et al. Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression. Int J Cancer. 2005 Mar 20;114(2):190-4. ↩
- Suzuki M, et al. Pharmacological effects of saw palmetto extract in the lower urinary tract. Acta Pharmacol Sin. 2009 Mar;30(3):271-81. ↩
- Fagelman E, et al. Saw Palmetto Berry as a Treatment for BPH. Rev Urol. 2001 Summer;3(3)134-8. ↩
- El-Sheikh MM, et al. The effect of Permixon on androgen receptors. Acta Obstet Gynecol Scand. 1988;67(5):397-9. ↩
- Altavilla D, et al. The combination of Serenoa repens, selenium and lycopene is more effective than serenoa repens alone to prevent hormone dependent prostatic growth. J Urol. 2011 Oct;186(4):1524-9. ↩
- Angwafor F 3rd, et al. An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. J Int Soc Sports Nutr. 2008 Aug 12;5:12. ↩
- Anderson ML, et al. Evaluation of Resettin® on serum hormone levels in sedentary males. J Int Soc Sports Nutr. 2014 Aug 23;11:43. ↩
- Strauch G, et al. Comparison of finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase in healthy male volunteers. Eur Urol. 1994;26(3):247-52. ↩
- Suter A, et al. Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial. Phytother Res. 2013 Feb;27(2):218-26. ↩
- Barry MJ, et al. Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial. JAMA. 2011 Sep 28;306(12):1344-51. ↩
- Wilt TJ, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA. 1998 Nov 11;280(18):1604-9. ↩
- Di Silverio F, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol. 1992;21(4):309-14. ↩