Animal & Petri Dish Researchorting-immune-system-function">Supporting immune system functionProbiotic bacteria have a wide range of immunity benefits.
Probiotics are bacteria that can have a positive impact on your health. Probiotics seem to support healthy immune system function through:
- Stimulating immune function. Probiotics can stimulate immune cells and modulate cytokines.
- Protection from pathogens. Probiotics can compete with and kill off harmful bacteria and other pathogens.
- Enhancing the intestinal barrier. This cell layer protects the body from toxins and other harmful compounds, and its disruption plays a role in immune and inflammatory conditions.
Probiotics, also known as “good” bacteria, are microorganisms that can benefit your health. These bacteria are naturally present in the gut as part of a complex microbiota community that aids digestion, produces vitamins, and protects you from disease-causing microorganisms. Probiotics can also be found in a variety of fermented foods and are sold as dietary supplements.
Disruption of gut microbiota is now believed to play a key role in the development of gastrointestinal disorders. Furthermore, research indicates that probiotics also affect and improve other areas of your health such as immune function.
Although current findings on the immunity benefits of probiotics are conflicting, this might be explained by the fact that the individuals studied vary in their genetic background, diet, and gut microbiota composition, as well as the fact that different probiotic species and strains have different effects.
How Probiotics Might Help With Immunity>Supporting immune system function
Researchers propose that probiotics can enhance immune function via multiple mechanisms, including: competing with pathogens and releasing compounds that kill off harmful bacteria; promoting the survival and defensive function of the intestinal mucosal barrier, a layer of cells that lines the intestine; and affecting the immune system directly by stimulating immune cell activity and modulating levels of cytokines – protein molecules that play a key role in inflammation. 1 2
Probiotics Uses & Benefits for ImmunityProbiotics have a wide range of research-backed immunity uses and benefits, including helping with immunity-related conditions such as allergies, eczema, viral and bacterial infections, and inflammatory conditions such as IBS and IBD. They might even help with autoimmune conditions such as rheumatoid arthritis, although more research is needed. 3
The one thing to keep in mind, however, is that all probiotics don’t have the same effect because of personal genetic and gut microbiota differences, as well as differences between probiotic strains. In addition, current research suggests that probiotics provide little to no benefit to people who are already healthy, and likely have a well-balanced gut glora.4
Research>Animal & Petri Dish Research
Probiotics have been extensively researched as immune system modulators in animals and cell culture studies, suggesting benefits such as:
- Reduced inflammation. Probiotics have been shown to modulate levels of cytokines and chemokines, compounds that play a significant role in inflammation and inflammatory conditions such as colitis.5 6
- Improvement of allergies. Probiotics have been shown to reduce allergies in mice models of food, pollen, and other types of allergy.7 8
Human Researchrobiotics have been shown to help with immunity in multiple ways, including enhancing overall immune function and helping with specific conditions such as allergies, infections, and inflammatory illnesses.
This study tested whether probiotics can enhance immunity in the elderly. Thirty older adults (age 63-84) took low-fat milk daily for 3 weeks, followed by milk with a low or standard dose of the probiotic B. lactis HN019 daily for 3 more weeks, and low-fat milk for another 3 weeks. After taking the probiotic, the participants had increased proportions of total, helper, and activated T lymphocyte and natural killer (NK) cells, in addition to enhanced activity of phagocyte and NK cells.
- The researchers concluded that “B. lactis HN019 could be an effective probiotic dietary supplement for enhancing some aspects of cellular immunity in the elderly.”9
This randomized, double-blind, placebo-controlled study explored the efficacy of probiotics for reducing short-term illness. One hundred and eighty-one employees received placebo or an L. reuteri probiotic daily for 80 days. The L. reuteri group had fewer reports of sick leave (10.6% ves 26.4%) and lower frequency of sick days (0.4% vs 0.9%) than placebo. In addition, while 33% of placebo shift-workers were sick during the study, none in the L. reuteri group reported being sick.
- The researchers concluded that “…L. reuteri is effective to promote work-place healthiness.”10
The efficacy of probiotics in irritable bowel syndrome (IBS) was examined in a double blind, randomized, placebo-controlled study. Fifty-two people were given a probiotic mixture (including two strains of Lactobacillus acidophilus, Bifidobacterium lactis, and Bifidobacterium bifidum) or placebo daily for 8 weeks. Compared to placebo, the probiotic group had greater improvement in symptom severity, quality of life, days with pain, and bowel habits.
- The researchers concluded that “LAB4 multistrain probiotic supplement may benefit subjects with IBS.”11
This randomized, double-blind, placebo-controlled study tested whether probiotics can ward off digestive and respiratory tract infections in children. Two hundred and eighty-one children attending day care centers were given a placebo dairy drink or the same drink containing Lactobacillus GG (LGG) daily for 3 months. Children in the LGG group had lower risk of upper respiratory tract infections (URTIs) and URTIs lasting more than 3 days, along with fewer days with symptoms.
- The researchers concluded that “LGG administration can be recommended as a valid measure for decreasing the risk of upper respiratory tract infections in children attending day care centers.”12
This randomized, double-blind, placebo-controlled study, tested the effects of probiotics on the common cold infection. Two hundred and seventy-two adults were given a mixture of two Lactobacillus strains (Lactobacillus plantarum HEAL 9 and Lactobacillus paracasei 8700:2) or placebo daily for 12 weeks. The probiotics group had lower occurrence of 1 or more cold infections (55% versus 67% for placebo), fewer days with cold symptoms, and a lower symptom score.
- The researchers concluded that “…intake of the probiotic strains Lactobacillus plantarum HEAL 9 (DSM 15312) and Lactobacillus paracasei 8700:2 (DSM 13434) reduces the risk of acquiring common cold infections.”13
This double-blind, randomized, placebo-controlled study looked at the immunity effects of two probiotic strains – Bifidobacterium animalis ssp.lactis and Lactobacillus paracasei ssp.paracasei. Two hundred and eleven people were given placebo or one of the two probiotics in capsules or a dairy drink daily for 6 weeks. Two weeks later, they received a vaccine against influenza. Both probiotic groups saw greater changes in levels of several antibodies compared to placebo.
- The researchers concluded that “Data herein show that supplementation with BB-12 L. casei 431 may be an effective means to improve immune function…“14
This randomized, double-blind, placebo-controlled trial examined whether probiotics can help children with allergies. One hundred and five children (age 6-12) with asthma and allergic rhinitis (AR) were given placebo or an L. gasseri A5 probiotic daily for 2 months. Kids given the probiotic saw significant improvement of lung function, asthma and AR symptoms, in addition to a reduction in inflammatory markers such as TNF-α, IFN-γ, IL-12, and IL-13.
- The researchers concluded that “…probiotic supplementation may have clinical benefits for school children suffering from allergic airway diseases such as asthma and AR.”15
Dosage for Immunityiven the wide variety of probiotic strains and mixes used in research, there is no standard dose
Supplements in Review Saysstrong>Probiotic containing multiple strains, daily for immunity.
We recommend probiotics for enhancing immune function. Unless you follow a very healthy diet or eat plenty of probiotic foods, chances are you could see some immunity benefits from supplementing with probiotics.
Look for a supplement that provides multiple probiotic strains. Because different probiotics have different effects, and because your gut already contains a wide variety of beneficial bacteria, supplements that contain multiple probiotic strains will likely be more effective.
- Kwon HK et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2159-64. ↩
- Yan F and Polk DB. Probiotics and immune health. Curr Opin Gastroenterol. 2011 Oct; 27(6): 496–501. ↩
- Vaghef-Mehrabany E et al. Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis. Nutrition. 2014 Apr;30(4):430-5. ↩
- https://www.ncbi.nlm.nih.gov/pubmedhealth/behindtheheadlines/news/2016-05-12-no-evidence-probiotics-are-beneficial-for-healthy-adults/ ↩
- Foligne B et al. Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria. World J Gastroenterol. 2007 Jan 14;13(2):236-43. ↩
- von Schillde MA et al. Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines. Cell Host Microbe. 2012 Apr 19;11(4):387-96. ↩
- Schiavi E et al. Oral therapeutic administration of a probiotic mixture suppresses established Th2 responses and systemic anaphylaxis in a murine model of food allergy. Allergy. 2011 Apr;66(4):499-508. ↩
- Schabussova I et al. Distinctive anti-allergy properties of two probiotic bacterial strains in a mouse model of allergic poly-sensitization. Vaccine. 2011 Feb 24;29(10):1981-90. ↩
- Gill HS et al. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am J Clin Nutr. 2001 Dec;74(6):833-9. ↩
- Tubelius P et al. Increasing work-place healthiness with the probiotic Lactobacillus reuteri: a randomised, double-blind placebo-controlled study. Environ Health. 2005 Nov 7;4:25. ↩
- Williams EA et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2009 Jan;29(1):97-103. ↩
- Hojsak et al. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2010 Jun:29(3):312-316. ↩
- Berggren A et al. Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections. Eur J Nutr. 2011 Apr;50(3):203-10. ↩
- Rizzardini G et al. Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study. Br J Nutr. 2012 Mar;107(6):876-84. ↩
- Chen YS et al. Randomized placebo-controlled trial of lactobacillus on asthmatic children with allergic rhinitis. Pediatr Pulmonol. 2010 Nov;45(11):1111-20. ↩