Bovine colostrum holds much promise as an all-around immune system supplement.
Colostrum is a special type of milk from cows that have recently given birth. Bovine colostrum may help the immune system through:
- Supplying immune factors. Bovine colostrum contains a wide range of natural compounds with antiviral, antimicrobial, anti-inflammatory, and immune-boosting properties.
Colostrum is a type of milk produced by mammals for a few days after giving birth. It contains a wide variety of nutrients, growth factors, antimicrobial, antiviral, and immune system-boosting compounds meant to promote growth, digestive health, and immunity in the newborn.
Although all mammals – including humans – produce colostrum, supplements are typically made from bovine sources, which are 100 – 1,000 times more potent.
Bovine colostrum has a wide range of medical uses, including boosting the immune system, helping heal injuries, alleviating inflammatory, autoimmune, and digestive disorders, promoting weight loss, and improving overall health. It is also popular with athletes, who believe that colostrum may help build muscle mass, lose fat, and improve physical performance.
How Colostrum Might Help With Immunity
Supplying compounds with antiviral, antimicrobial, immune-boosting, and anti-inflammatory properties
Bovine colostrum is rich in a wide range of natural ingredients that aid immunity directly by stimulating and enhancing the immune system, and indirectly through biological activities that help fight viruses, bacteria, fungi, and other pathogens.
The most notable beneficial compounds in bovine colostrum include: 1
- Lactoferrin, a protein that has antiviral,antimicrobial, and anti-inflammatory properties
- Immunoglobulins A, D, E, G, M, antibodies that help neutralize toxins and pathogens
- Proline-rich polypeptide (PRP), a compound that has been shown to help with allergies and autoimmune conditions
- Cytokines, molecules that are critically involved in the immune response and inflammation
- Lysozyme, an antimicrobial enzyme involved in immune system function
Colostrum Uses and Benefits for Immunity
Bovine colostrum – either in its natural liquid form or as a supplement – is quickly rising in popularity for helping with flu, cold, and other common infections, digestive disorders, inflammatory conditions, and for overall immune system support.
Although more human studies backing the various immune-related uses of colostrum are needed, the current stance of clinical researchers is that “There is emerging evidence that bovine colostrum (BC) may be one of the promising nutraceuticals which can prevent or mitigate various diseases in newborns and adults.”
Animal and Petri Dish Research
Animal and cell culture studies of bovine colostrum demonstrate that it:
- Contains compounds with antimicrobial, antiviral, and anti-inflammatory properties, as shown against isolated pathogens and in mice with paw inflammation2 3
- Improves the activity of natural killer cells and enhances the immune response to flu infection in mice 4
- Alleviates or entirely prevents flu infection in mice 5
- Stimulates the activity of human phagocyte cells, especially against specific bacteria the cows were immunized against6
- Helps heal gastrointestinal damage and injuries in mice 7
Research of bovine colostrum in humans is still in its early stages, but current findings suggest that it may help fight upper respiratory and flu infections and improve certain aspects of immune function.
This study examined the effects of colostrum supplementation on flu infections. In the first part of the study, 144 people were divided into 4 groups: no treatment, flu-vaccinated, colostrum only for 2 months, and flu-vaccinated plus colostrum for 2 months. They were followed up with a month later; the researchers found that the non-colostrum groups had 3 times more days sick with the flu.
In the second part of the study, 65 high-risk cardiovascular patients were divided into flu vaccine only, colostrum only, or vaccine plus colostrum groups. The vaccine-only group had higher occurrence of complications and hospital admission.
- The researchers concluded that “Colostrum, both in healthy subjects and high-risk cardiovascular patients, is at least 3 times more effective than vaccination to prevent flu and is very cost-effective.” 8
This placebo-controlled study examined the use of bovine colostrum for improving mucosal immunity, which may be particularly useful for reducing risk of upper respiratory tract infections. A total of 35 distance runners were given placebo or bovine colostrum daily for 12 weeks and had their saliva tested. Levels of salivary IgA (immunoglobulin A) went up by 79% in the colostrum group by the end of the study.
- The researchers concluded that “This study has demonstrated increased s-IgA levels among a cohort of athletes following colostrum supplementation.”9
This study examined data from previously done double-blind, placebo-controlled studies to see whether bovine colostrum can reduce the incidence or duration of upper respiratory tract infections (URTIs). In these studies, 174 participants were given 60 g of concentrated bovine colostrum (CBC) or whey protein daily for 8 weeks and reported any symptoms of URTI. A smaller number of people taking CBC reported URTI symptoms (32%) compared to those taking whey (48%).
- The researchers concluded that “This study provides preliminary evidence that CBC may enhance resistance to the development of symptoms of URTI.”10
In this randomized, double-blind study, 25 elite swimmers were given 25 g of bovine colostrum (BC) or placebo daily for 10 weeks. BC supplementation had no effect on immunoglobulin levels; however, after 4 weeks, fewer athletes in the BC group reported symptoms of upper respiratory tract infections (25%) than placebo (61%).
- The researchers concluded that “There was no measurable effect on immunoglobulin levels of consuming BC…Fewer athletes reported URS (although cause unknown) when consuming BC, which may be advantageous for training.”11
Dosage for Immunity
- Clinical studies have used different forms of colostrum, making it difficult to make dosage recommendations
- Most colostrum supplements come as a powder taken in scoops or in 500 mg capsules
- Liquid colostrum. The natural form of bovine colostrum with little to no processing.
- Colostrum powder. Dried bovine colostrum; the most common form used in supplements.
Supplements in Review Says
- Bovine colostrum powder 500 mg for immunity.
Bovine colostrum is one of the most promising immune system supplements. Although more clinical trials are sorely needed, there is a growing body of evidence that bovine colostrum provides a wide range of immunity-related benefits that can alleviate and ward off infections and illnesses.
500 mg capsules or powder seems to be the most convenient dose. Given the difficulty and cost of procuring colostrum in its natural, liquid form, dried colostrum powder is the next best option.
- Bagwe S et al. Bovine colostrum: an emerging nutraceutical. J Complement Integr Med. 2015 Sep;12(3):175-85. ↩
- Yadav R et al. Antibacterial and Antiinflammatory Properties of Bovine Colostrum. Recent Pat Inflamm Allergy Drug Discov. 2016;10(1):49-53. ↩
- Y. Pan et al. Antiviral properties of milk proteins and peptides. International Dairy Journal, Volume 16, Issue 11, November 2006, Pages 1252-1261. ↩
- Wong EB et al. Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4. Nutr Res. 2014 Apr;34(4):318-25. ↩
- Ng WC et al. Prevention and treatment of influenza with hyperimmune bovine colostrum antibody. PLoS One. 2010 Oct 26;5(10):e13622. ↩
- Loimaranta V et al. Colostral proteins from cows immunised with Streptococcus mutans/S. sobrinus support the phagocytosis and killing of mutans streptococci by human leucocytes. J Med Microbiol. 1999 Oct;48(10):917-26. ↩
- Kim JW et al. Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pac J Clin Nutr. 2005;14(1):103-7. ↩
- Cesarone MR et al. Prevention of influenza episodes with colostrum compared with vaccination in healthy and high-risk cardiovascular subjects: the epidemiologic study in San Valentino. Clin Appl Thromb Hemost. 2007 Apr;13(2):130-6. ↩
- Crooks CV et al. The effect of bovine colostrum supplementation on salivary IgA in distance runners. Int J Sport Nutr Exerc Metab. 2006 Feb;16(1):47-64. ↩
- Brinkworth GD and Buckley JD. Concentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males. Eur J Nutr. 2003 Aug;42(4):228-32. ↩
- Crooks C et al. Effect of bovine colostrum supplementation on respiratory tract mucosal defenses in swimmers. Int J Sport Nutr Exerc Metab. 2010 Jun;20(3):224-35. ↩
- Mitra AK et al. Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double-blind, controlled clinical trial. Acta Paediatr. 1995 Sep;84(9):996-1001. ↩
- Sarker SA et al. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J. 1998 Dec;17(12):1149-54. ↩