Animal Researche: 18pt;">Ashwagandha is one of the best natural ways to reduce anxiety, and might also improve depression and neurodegenerative conditions.
The ancient Indian herb ashwagandha has long been used to calm the mind and resist all sorts of stress. As a nootropic, its primary benefits seem to be:
- Reduction of anxiety. Ashwagandha reduces neuron activity, lowering anxiety and promoting relaxation.
- Neuroprotection. Ashwagandha’s antioxidant constituents help protect the brain from oxidative damage, which is particularly involved in neurodegenerative disorders.
- Potential improvement of mood. Early animal research indicates that ashwagandha may have antidepressant effects.
Ashwagandha (Withania somnifera) is a herb that has been used for many centuries in India’s traditional Ayurvedic medicine. As an adaptogen, ashwagandha helps the body adapt to all sorts of physical and mental stress. As such, it has a wide range of health applications, and has been used to help with issues including:
- Sexual health
- Stress, anxiety, and depression
- Neurodegenerative conditions
- Sleep problems
In addition, ashwagandha is often used as a nootropic by healthy individuals looking to reduce anxiety and promote relaxation. These and other uses of ashwagandha are backed by a growing number of research studies. In particular, this versatile herb has been demonstrated to have antioxidant, anxiolytic, antidepressant, cardioprotective, immuno-modulating, antimicrobial, anti-inflammatory, neuroprotective, and cognition-enhancing effects.<
How Ashwagandha Might Help the Brain<
Reducing neuron activity
Similar to many other anxiety-reducing herbs, such as Magnolia officinalis and skullcap, ashwagandha works primarily through influencing the brain’s GABAergic (related to the neurotransmitter GABA) activity. By activating the receptors used by GABA, ashwagandha reduces neuron activity and prevents excessive neuron firing. In turn, this effect results in reduction of anxiety and increased relaxation.1<
Ashwagandha is also known to contain antioxidants. These compounds can support brain health by reducing oxidative stress, which is particularly involved in the development of neurodegenerative disorders such as Parkinson’s and Alzheimer’s.<
Ashwagandha’s Nootropic Uses & Benefits
As a nootropic, ashwagandha is popular for reducing anxiety and stress and promoting calmness and relaxation. This use is backed by thousands of years of use and a growing number of clinical research studies.
Some people also use ashwagandha to help with neurodegenerative conditions such as Parkinson’s and Alzheimer’s, although the evidence for this is restricted to animal research. Finally, a single animal study also suggests that this versatile herb may have antidepressant effects.
Studies of ashwagandha supplementation in animals demonstrate that it may:
- Improve tolerance to chronic stress in mice2
- Protect rodents from dementia and other neurodegenerative disorders3 4
- Act as an antidepressant and anxiolytic in mice5
This double-blind, randomized study examined ashwagandha’s anxiolytic effect. Thirty-nine people with anxiety disorder were given ashwagandha extract (500 mg) or placebo daily for six weeks. The ashwagandha dose was lowered or raised at two weeks for each patient depending on efficacy and side effects. Compared to placebo, the ashwagandha group showed a trend towards reduced anxiety at week 2, and had significantly reduced anxiety at week 6.
- The researchers concluded that “ethanolic extract of Withania somnifera has useful anxiolytic potential and merits further investigation.“6
In this randomized trial, 81 adults with moderate to severe anxiety followed one of two interventions for 12 weeks – PT: standard psychotherapy with deep breathing techniques; or NC: deep breathing plus dietary counseling, a multi-vitamin, and ashwagandha (300 mg standardized to 1.5% anolides). Improvement was measured by the Beck Anxiety Inventory (BAI) and quality of life measures.
The NC group improved BAI score by 56.5%, compared to only 30.5% for PT. The NC group also had greater improvement in mental health, fatigue, vitality, and overall quality of life.
- The researchers concluded that “Withania somnifera, a multi vitamin, dietary counseling and cognitive-behavioral therapy appears to be a safe and effective, with benefit over standardized psychotherapy in the treatment of mild to severe generalized anxiety.“7
This double-blind, randomized study examined the efficacy of ashwagandha in helping with stress and anxiety in stressed adults. Sixty-four people with chronic stress were given placebo or ashwagandha extract (600 mg) daily for 60 days. Compared to placebo, the ashwagandha group saw significant improvement on all scores of stress assessment, also a reduction in serum cortisol (stress hormone) levels.
- The researchers concluded that “high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual’s resistance towards stress and thereby improves self-assessed quality of life.“8
In this randomized, placebo-controlled study, 53 patients diagnosed with bipolar disorder were supplemented with placebo or ashwagandha (250 mg first week, 500 mg for 7 more weeks). Compared to placebo, ashwagandha treatment demonstrated significant improvements in tests of memory, reaction time, and social cognition. Mood and anxiety scale scores were not changed following treatment.
- The researchers concluded that “WSE appears to improve auditory-verbal working memory (digit span backward), a measure of reaction time, and a measure of social cognition in bipolar disorder.”9
Nootropic Dosage>Successful clinical trials have used doses of 300 – 600 mg ashwagandha
Supplements in Review Saysrong>Ashwagandha root extract 300 – 600 mg.
We highly recommend ashwagandha for anxiety. Ashwagandha is an effective way to boost brain function in people with excessive anxiety and stress, and the potential neuroprotective and antidepressant effects are a great bonus.
300 – 600 mg seems to be the ideal dosage range. We recommend taking a supplemental extract with a maximum dosage of 600 mg daily.
- Candelario M, et al. Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABArho receptors. J Ethnopharmacol 2015;171: 264-272 ↩
- Bhattacharya SK, et al. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav 2003;75(3): 547-555 ↩
- Ahmad M, et al. Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats. Hum Exp Toxicol 2005;24(3): 137-147 ↩
- Kuboyama T et al. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. 2005 Apr;144(7):961-71. ↩
- Bhattacharya SK et al. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000 Dec;7(6):463-9. ↩
- Andrade C et al. A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera. Indian J Psychiatry. 2000 Jul;42(3):295-301. ↩
- Cooley K et al. Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS One. 2009 Aug 31;4(8):e6628. ↩
- Chandrasekhar K et al. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62. ↩
- Chengappa KN, et al. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry 2013;74(11): 1076-1083 ↩
- Katz M, et al. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. J Atten Disord 2010;14(3): 281-291 ↩