Animal Researche: 18pt;">Early research suggests that the golden poppy plant may reduce anxiety.
Traditionally viewed as a sedative and anxiolytic, California poppy is believed to offer one major nootropic effect:
- Anxiolytic activity. California poppy has demonstrated the potential to reduce anxiety and promote relaxation.
California poppy (Eschscholzia californica), nicknamed “cup of gold,” is a variety of the poppy plant native to the west coast of the U.S. and Mexico. Traditionally, Native Americans used its parts (mainly the seeds, leaves, and pollen) as a coloring agent and food source. The whole plant has also been used as an herbal remedy, with medical research suggesting that it has several medicinal properties:
- Analgesic (pain-reducing)
- Anxiolytic (anxiety-reducing)
- Antihistaminic (anti-allergic)
How California Poppy Might Help the Brain<
Enhancing GABA activity
Gamma aminobutyric acid (GABA) is a calming neurotransmitter known to reduce anxiety. California poppy has shown the ability to bind to its receptors, enhancing GABA’s impact as a result. Although the precise mechanism is still being investigated, the alkaloid substance S-reticuline may be the compound responsible.2 By triggering GABA, California poppy may potentially impart sedative, analgesic, and anxiolytic effects.3<
Binding to 5-HT receptors
The alkaloids present in California poppy have also been shown to bind to and activate serotonin receptors 5-HT(1A) and 5-HT(7), which is associated with a number of effects common to nootropics including: 4
- Releasing dopamine and serotonin5
- Managing the release of norepinephrine6
- Improving cognitive function associated with the prefrontal cortex, such as planning, decision making, and confidence in social behavior7
- Regulating mood and sleep patterns8
California Poppy Potential Nootropic Benefits & Uses
California poppy is taken to promote calmness, reduce anxiety, combat depression, and improve sleep. However, only its ability to alleviate anxiety has been demonstrated in a clinical setting thus far.
Despite lack of scientific backing, California poppy has popularly been ingested, smoked, or brewed for its purported psychotherapeutic effects. The supposed mild euphoria it causes has even led some to use as a substitute for marijuana.
In this investigation, mice administered either 100 or 200 mg of a California poppy extract per kg of body weight were found to have reduced movement behavior and increased sleep induction. Moreover, mice administered 25 mg/kg of the extract improved their anti-conflict activity as indicated by an increased average number of steps taken on a staircase test and amount of time spent in a box.
- The researchers concluded that “this finding validates its traditional sedative properties confirmed by the sleeping induction at doses above 100 mg/kg. Furthermore, when administered at a dose a of 25 mg/kg, E. californica appeared to also have an anxiolytic action.”9
Human Researchyle="line-height: 18.0pt;">California poppy as Sympathyl® (80 mg) may help treat mild to moderate anxiety
In this double-blind, randomized, placebo-controlled investigation, 264 patients with mild to moderate generalized anxiety were given either a placebo or a 2 tablets of a drug containing fixed quantities of 2 plant extracts (20 mg of Eschscholtzia californica and 75 mg of Crataegus oxyacantha per pill) and magnesium known as Sympathyl® twice a day for 3 months. The Sympathyl group experienced greater improvement than placebo in anxiety score and subjective anxiety.
- The researchers concluded that “Crataegus oxyacantha, Eschscholtzia californica, and magnesium proved safe and more effective than placebo in treating mild-to-moderate anxiety disorders.”10
Nootropic Dosagenly successful clinical research study administered 40 mg of California poppy extract combined with Crataegus oxyacantha and magnesium.
Supplements in Review Saysn style="font-size: 14pt;">California poppy 400 – 1500 mg as a nootropic.
Early research suggests California poppy may reduce anxiety. California poppy supplementation is still in its exploratory stages, but current evidence suggests that it has anxiety-reducing effects.
Take low supplement doses of California poppy. We recommend starting at the lowest available supplemental dose of California poppy, which appears to be approximately 400 mg.
- Macleod BP, et al. Methods for regeneration and transformation in Eschscholzia californica: A model plant to investigate alkaloid biosynthesis. Methods Mol Biol. 2006;318:357-68. ↩
- Fedurco M, et al. Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors. Biochem Res Int. 2015;2015:617620. ↩
- Rolland A, et al. Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae). Phytother Res. 2001 Aug;15(5):377-81. ↩
- Gafner S, et al. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of 3H8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. J Nat Prod. 2006 Mar;69(3):432-5. ↩
- Naumenko VS, et al. Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders. CNS Neurosci Ther. 2014 Jul;20(7):582-90. ↩
- Cahlikova L, et al. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). Nat Prod Commun. 2010 Jul;5(7):1035-8. ↩
- Meltzer HY, et al. Does stimulation of 5-HT(1A) receptors improve cognition in schizophrenia? Behav Brain Res. 2008 Dec 16;195(1):98-102. ↩
- Hedlung PB, et al. Functional, molecular and pharmacological advances in 5-HT7 receptor research. Trends Pharmacol Sci. 2004 Sep;25(9):481-6. ↩
- Rolland A, et al. Behavioural effects of the American traditional plant Eschscholzia californica: sedative and anxiolytic properties. Planta Med. 1991 Jun;57(3):212-6. ↩
- Hanus M, et al. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Curr Med Res Opin. 2004 Jan;20(1):63-71. ↩