Animal Researchsection" id="protecting-muscles-from-oxidative-stress">Protecting muscles from oxidative stress sports supplement creatine helps maximize muscle gains from resistance training and may potentially aid in recovery.
The organic compound creatine has a long history of use in athletic nutrition. It has specifically been shown to carry such potential post workout benefits as:
- Improving muscle and strength gains. Creatine helps you train harder, resulting in improved muscle and strength gains.
- Potentially enhancing muscle recovery. Limited evidence suggests that creatine may aid muscle recovery by reducing exercise-induced damage.
Creatine is a naturally occurring compound produced by the body and also available in food. The large majority of creatine is found in skeletal muscle —with minor quantities distributed in the brain and blood—which is why it was named after the Greek word for meat.
Creatine’s primary function is to help sustain adenosine triphosphate (ATP) supplies in muscle tissue, which is the body’s main source of energy. As such, supplementing creatine can help increase performance during high-intensity exercise that rapidly drains ATP.
Creatine is arguably the most widely consumed and effective workout supplement worldwide, especially for those seeking to improve muscle mass, such as bodybuilders. More than simply a means of improving high-intensity performance, early research suggests that creatine might also enhance muscle recovery, boost testosterone levels, and enhance brain function.1
How Creatine Might Help Post Workout Formulastecting muscles from oxidative stress
One of the consequences of working out is oxidative stress, which can damage muscles. Creatine has been suggested to reduce muscle damage and inflammation caused by exercise-induced oxidative stress, ultimately aiding in muscle recovery.2
Potential modulation of proteins regulating muscle growthesearch indicates that creatine may be capable of stimulating muscle growth by affecting several proteins that govern muscle mass. Researchers suggests several mechanisms:
However, whether this effect is simply the result of improved anaerobic performance or a separate set of biological mechanisms remains unknown.
Creatine’s Post Workout Benefits & Usestine does not need to be taken specifically after a workout, it does provide several post-workout benefits when taken regularly. First and foremost, creatine results in larger muscle mass and strength gains through the simple fact of allowing you to workout longer and/or at higher intensity. This effect has been consistently demonstrated by clinical research.
There is also some early evidence that creatine may aid post-workout muscle recovery by reducing exercise-induced muscle damage, resulting in tangible benefits such as reduced soreness after a strenous workout. 6 7
Creatine supplementation has consistently been cited as benefiting the growth, strength, and overall well-being of muscle tissue in animals. Some of the main post workout advantages include:
Human Researchht: 18.0pt;">Numerous clinical studies have demonstrated creatine’s capacity to bolster muscle mass after resistance training, and potentially improve muscle recovery.
In this double-blind investigation, 27 males were divided into 3 groups: control, resistance training with placebo, and resistance training with creatine. The training was 3 days a week for 8 weeks and consisted of 3 sets of 8-10 reps of strength testing. Creatine with resistance training was found to result in larger muscle gains than training alone, an effect the researchers attributed to decreased levels of myostatin.
- The study concluded that “the present study is the first to demonstrate that decreasing myostatin and inhibiting its function by GASP-1 may play important role in increasing muscle strength and mass by resistance training, and supplementation with creatine resulted in greater increases in muscle mass and strength, and this improvements were accompanied by more decreased myostatin levels.”11
In this double-blind investigation, 14 bodybuilders were given either a placebo or 10 grams of creatine every day while training 3 days a week throughout a 6-week period. The creatine group gained nearly twice the body mass of the placebo group (4.3 kg versus 2.1 kg) as well as twice the muscle girth, especially in the chest, thighs, and biceps.
- The study concluded that “the 6-week oral administration of creatine (10 g daily) to bodybuilders…brought about significantly greater increases in body mass and some body circumferences compared with the control group, both in the relaxed and contracted muscle states.”12
In this randomized study, 8 triathletes received either a placebo or 20 grams of creatine daily for 5 days and then participated in an extremely rigorous physical competition known as the Ironman triathlon. Creatine supplementation was reported to reduce creatine kinase (CK) and lactate dehydrogenase (LDH) levels, both of which are markers of muscle damage.
- The study concluded that “CrS presented a protective effect on muscle injury induced by strenuous contractile activities.”13
In this randomized, double-blind investigation, 28 seniors completed a whole-body resistance exercise program 3 times a week for a total of 14 weeks. In addition, participants either took a placebo or 5 grams of creatine monophosphate daily. Creatine supplementation resulted in significant increases in fat-free body mass, improvements in all strength and functional exercises, and increases in knee extension strength.
- The study concluded that “the addition of CrM supplementation to the exercise stimulus enhanced the increase in total and fat-free mass, and gains in several indices of isometric muscle strength.”14
This meta-analysis examined the impact of creatine supplementation during a period of regular resistance training on a total of 357 older adults. Creatine was found to significantly increase fat-free body mass, improve chest and leg press performance, and improve knee extension compared to the placebo.
- The researchers concluded that “the results from this meta-analysis are encouraging in supporting a role for Cr supplementation during RT in healthful aging by enhancing muscle mass gain, strength, and functional performance over RT alone.”15
In this double-blind investigation, 23 experienced weight lifters were given either a placebo or 5 grams of a creatine monohydrate drink daily for 5 days and then 2 grams every day after that throughout their strength training. Arm flexion and fat-free body mass increased significantly more for the creatine group than that of the placebo.
- The study concluded that “creatine supplementation during arm flexor strength training lead to greater increases in arm flexor muscular strength, upper arm muscle area, and fat-free mass than strength training alone.”16
Dosage for Post Workout
Dosage for Post Workoute a creatine “loading” protocol for which a 20 – 25 gram (or 0.3 gram/kg body weight) creatine monohydrate is taken as 4 – 5 daily doses for up to a week, after which a steady daily dose of 3 – 5 grams (0.03 g/kg) is taken
- The typical daily supplemental dose is 5 grams, which maintains maximum muscle creatine levels
- Creatine monohydrate is the most popular due to its heavy clinical backing. Check out the various other types of creatine supplements here.
Supplements in Review Says
Supplements in Review Saystine monohydrate 5 g daily.
We highly recommend creatine for post workout recovery. With tons of research supporting the safety and efficacy of supplemental creatine, we recommend it as arguably the most potent, safe way to boost muscle gains after workouts, and potentially improve muscle recovery.
Stick with 5 grams of creatine monohydrate daily. Creatine monohydrate is the preferred form of supplemental creatine and seems to be most effective when taken at 5 g daily.
- Smith RN, et al. A review of creatine supplementation in age-related diseases: more than a supplement for athletes. F1000Res. 2014 Sep 15;3:222. ↩
- Sestili P. et al. Creatine as an antioxidant. Amino Acids. 2011 May;40(5):1385-96. ↩
- Deldicque L, et al. Increased IGF mRNA in human skeletal muscle after creatine supplementation. Med Sci Sports Exerc. 2005 May;37(5):731-6. ↩
- Burke DG, et al. Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults. Int J Sport Nutr Exerc Metab. 2008 Aug;18(4):389-98. ↩
- Willoughby DS and Rosene J. Effects of oral creatine and resistance training on myosin heavy chain expression. Med Sci Sports Exerc. 2001 Oct;33(10):1674-81. ↩
- Kim J, et al. Role of creatine supplementation in exercise-induced muscle damage: A mini review. J Exerc Rehabil. 2015 Oct; 11(5): 244–250. ↩
- Cooke M, et al. Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals. J Int Soc Sports Nutr. 2009; 6: 13. ↩
- Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab. 2003 Jun;13(2):198-226. ↩
- Araujo M, et al. Creatine supplementation and oxidative stress in rat liver. J Int Soc Sports Nutr. 2013;10:54. ↩
- Yildiz A, et al. The effects of Creatine Long-Term Supplementation on Muscle Morphology and Swimming Performance in Rats. J Sports Sci Med. 2009 Dec;8(4):516-22. ↩
- Saremi A, et al. Effects of oral creatine and resistance training on serum myostatin and GASP-1. Mol Cell Endocrinol. 2010 Apr 12;317(1-2):25-30. ↩
- Jagiello W, et al. Effects of creatine supplementation on body mass and muscle girths in bodybuilders. Biomedical Human Kinetics. 2010 Jun 24;2(1):47-50. ↩
- Bassit RA, et al. Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity. Eur J Appl Physiol. 2010 Mar;108(5):945-55. ↩
- Brose A, et al. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol Sci Med Sci. 2003 Jan;58(1):11-9. ↩
- Devries MC, et al. Creatine supplementation during resistance training in older adults-a meta-analysis. Med Sci Sports Exerc. 2014 Jun;46(6):1194-203. ↩
- Becque MD, et al. Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exerc. 2000 Mar;32(3):654-8. ↩