Pantesin® is a clinically researched, high-quality form of pantethine suggested to help balance cholesterol levels.
Pantesin is a branded version of panthethine, a natural derivative of vitamin B5. Pantesin’s research-supported potential to balance cholesterol levels has led to its frequent inclusion in cardiovascular health supplements. In comparison to basic pantethine preparations, Pantesin has three key advantages:
- Clinically Researched. Both Japanese and more recently North American research studies attest to Pantesin’s safety and efficacy.
- High quality. Pantesin is made through a pharmaceutical-grade manufacturing process.
- Established. Pantesin has been used in Japan for over four decades, testifying to its reliability.
Pantesin is a branded, pharmaceutical grade form of pantethine, a compound made from vitamin B5. Pantethine is widely used as a heart health supplement because of strong evidence that it lowers cholesterol while simultaneously raising HDL (“good”) cholesterol. Indeed, multiple clinical studies have reported that this natural compound improves blood lipid (fat) levels in individuals with high cholesterol and triglyceride levels.
Manufactured by Japanese biotech company Kyowa Pharma Chemical Co., Pantesin has been researched & sold in Japan for over 40 years, and became available in the U.S. in 1992. Pantesin is superior to basic pantethine in three major ways:
- Pharmaceutical-grade manufacturing process
- High-quality clinical research evidence
- Long track record of safety & efficacy
Pantesin panthethine works by increasing the activity of coenzyme A (COA), a compound that participates in over 100 biochemical reactions. One of COA’s functions is to break down cholesterol, triglycerides, and other lipid (fat) molecules. Because of this, increasing COA activity can help lower elevated cholesterol levels, resulting in improved blood circulation and heart health. In addition, Pantesin also benefits cardiovascular health through its antioxidant effects.
Pantesin comes in two forms:
- Pantesin HF55 – powder form of Pantesin
- Pantesin LQ80 – the less commonly used liquid form of Pantesin
Pantesin Nutritional Supplement Uses
Pantesin is most commonly used to reduce elevated cholesterol levels. It can be sold both by itself and mixed with other cholesterol-lowering ingredients such as artichoke extract. In addition, Pantesin can help:
- Maintain a healthy balance between HDL (“good”) and LDL (“bad”) cholesterol
- Support healthy blood vessels and fight atherosclerosis
Pantesin is also sometimes mixed with ingredients that reduce blood glucose levels, because elevated lipid and glucose levels often go hand in hand.
Compared to basic pantethine supplements, Pantesin is:
- Backed by trusted research: Although basic pantethine is also supported by research, most of it is small-scale and decades-old. Pantesin, on the other hand, is backed by numerous Japanese studies, as well as recent randomized controlled trials (RCTs) – the gold standard of clinical research.
- High-quality: Pantesin is a high-quality, highly absorbable, pharmaceutical-grade form of pantethine.
- Established: Japanese clinicians have used Pentasin for over four decades, which highlights both its efficacy and safety.
In addition to numerous Japanese studies, Pantesin’s ability to lower cholesterol is backed by two high-quality North American clinical trials.
This randomized, placebo-controlled, triple-blind study examined the effects of pantesin on cholesterol in people with low to moderate cardiovascular disease (CVD) risk. A total of 120 participants followed a therapeutic lifestyle change (TLC) diet for 16 weeks and were split into two groups at week 4: one receiving placebo and the other pantesin (600 mg to week 8, 900 mg week 9-16) daily. The pantesin group saw greater improvements in total cholesterol and LDL (“bad”) cholesterol than the TLC diet alone.
- The researchers concluded that “…pantethine supplementation for 16 weeks (600 mg/d for weeks 1-8 then 900 mg/d for weeks 9-16) is safe and significantly lowers TC and LDL-C over and above the effect of TLC diet alone.” 1
In this follow-up randomized, placebo-controlled, triple-blind study, adults with low to moderate cardiovascular disease (CVD) risk were given pantesin (600 mg week 1-8, 900 mg week 9-16) or placebo daily for 16 weeks. Unlike placebo, the pantesin group experienced a significant reduction of total, LDL ( “bad”) cholesterol, and non-HDL cholesterol.
- The researchers concluded that “This study confirms that pantethine lowers cardiovascular risk markers in low to moderate CVD risk participants eligible for statins according to NCEP guidelines.” 2
- Standalone Pantesin supplements typically come in 300-600 mg capsules
- Multi-ingredient cardiovascular health formulations typically contain 300 mg of Pantesin
- 600 mg is the most common dose used in human studies
Supplements in Review Recommendation
- Pantesin®, 300 mg 1-2 times daily.
Pantesin is the most trusted form of pantethine on the market. Having been used in Japan for four decades and backed by Japanese and more recently North American clinical trials, Pantesin is the highest-quality, most researched type of pantethine available.
Research suggests that 600 mg is the best dose. Although researchers have also tested doses of 900 mg, these did not have any additional benefits over taking 600 mg daily.
- Rumberger JA et al. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr Res. 2011 Aug;31(8):608-15. doi: 10.1016/j.nutres.2011.08.001. ↩
- Evans M et al. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vasc Health Risk Manag. 2014 Feb 27;10:89-100. ↩