WellTrim®

WellTrim® is a patented African mango extract clinically shown to promote fat loss.

WellTrim is one of the premier African mango extracts on the market today. Users most often take the extract to facilitate weight management. This review details its possible advantages over generic brands, which include the following:

• Clinical research. Clinical studies have suggested that WellTrim can be an effective fat loss supplement. That doesn’t mean that all generic African mango extracts are ineffective or any less effective—it largely depends on the brand.
• Patents. The production of WellTrim is protected by multiple U.S. patents. This, again, doesn’t necessarily mean superior effectiveness and safety, it only gives us confidence in the stability and consistent quality of the formula between batches.
• Safe. WellTrim has been generally recognized as safe for human consumption by multiple agencies, including the U.S. Food and Drug Administration (FDA).

Overview

WellTrim (IGOB131) is a branded and patented extract of African mango (Irvingia gabonensis) tree seeds. California-based company Gateway Health Alliance invented the product’s formulation. Its distribution is handled by Nuvocare, and its marketing is managed by Icon Group.

Currently, WellTrim is among African mango extract brands available that have backing from clinical studies as an all-natural ingredient for healthy weight management. Although there are many companies that produce African mango extracts, WellTrim has a patented proprietary manufacturing process that is claimed to retain all of the plant’s native fat-burning mechanisms.

As such, WellTrim is suggested as capable of bolstering a wide variety of health benefits related to fat loss, from reducing appetite and boosting energy metabolism to impeding the formation of fat cells through adipogenesis.

How WellTrim Works

WellTrim operates through multiple metabolic pathways to potentially help burn fat: ¹

1. Inhibiting the activity of glycerol-3-phosphate dehydrogenase, an enzyme that contributes to the storage of fat cells via lipogenesis.
2. Lowering the expression of peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor that contributes to obesity.
3. Enhancing the function of leptin — a hormone that helps regulate fat stores — by reducing the amount of C-reactive protein in the blood.
4. Up-regulating the expression of the hormone adiponectin. (Low levels of adiponectin are associated with higher body weight and fat content.)

WellTrim Patents

WellTrim preparation

Gateway Health Alliance has various patents and trademarks protecting its proprietary technique for making WellTrim and similar African mango extracts. U.S. Patent 7537790 covers the company’s method for using African mango seeds to reduce fat content, cholesterol levels, blood glucose, and a number of other factors related to body weight.

WellTrim Nutritional Supplement Uses

Fat Loss Supplements

Seeds from the African mango tree are commonly taken for weight management because of its rich store of bioactive ingredients, many of which block the production of fat cells. As a refined version of the seed extract, WellTrim is promoted as a fat loss supplement that may be able to impart various effects:

• Decreasing appetite
• Boosting metabolism
• Lowering “bad” LDL cholesterol levels
• Inhibiting the conversion of glucose into body fat

What’s more, the supplement has demonstrated a capacity to improve insulin sensitivity — a benefit that can help combat diabetes.

WellTrim Research

Human Research

One major randomized controlled trial, detailed below, stands out among several clinical studies claiming that African mango can support fat loss and facilitate weight management.

WellTrim (300 mg) may improve body weight, body fat, and waist circumference in overweight individuals

In this double-blinded, randomized, placebo-controlled investigation, 102 overweight or obese people took either a placebo or 150 mg of WellTrim before lunch and dinner for a 10-week period. The WellTrim group had statistically significant improvements to average measures of body weight (loss of 28 pounds), body fat (loss of 6.3%), and waist circumference (loss of 6.7 inches), as well as cholesterol, glucose, adiponectin, and leptin levels, compared with the placebo.

• The researchers concluded that WellTrim “administered 150 mg twice daily before meals to overweight and/or obese human volunteers favorably impacts body weight.”²

WellTrim Dosage

• Successful clinical trials have used 300 mg of WellTrim as 2 separate 150 mg doses.
• Typical WellTrim brand supplements come in daily servings sizes of 150 – 300 mg.