Longvida® is an innovative, clinically-proven ingredient that solves curcumin’s longstanding absorption problems.
- High Absorption. Patented solid lipid particle technology improves curcumin’s bioavailability & absorption by at least 65x of generic curcumin extracts.
- Brain-friendly. Longvida was designed particularly for getting curcumin cross the blood-brain barrier, which enhances its brain-protective effects.
- Clinically Researched. Longvida’s cardiovascular, cognitive, antioxidant, and other health benefits are backed by high-quality human studies.
- Reputable. Longvida was designed through a decade-long partnership between researchers at UCLA and Verdure Sciences.
Longvida is a patented curcumin extract made by American company Verdure Sciences. Curcumin is the main active ingredient of the herb turmeric, which is widely used for its anti-inflammatory and antioxidant effects. In fact, curcumin is one of the most researched herbal remedies in the world, and has been investigated as a therapeutic option for arthritis, digestive, cardiovascular, and skin disorders, Alzheimer’s and other neurodegenerative conditions, and more.
However, curcumin’s amazing potential has always been limited by its notoriously low bioavailability, which means that it is difficult for the body to absorb and use. Longvida remedies this problem by utilizing patented SLCP (Solid Lipid Curcumin Particle) technology which coats curcumin with a lipid matrix to greatly enhance its absorption.
Developed through a collaborative effort between plant ingredient manufacturer Verdure Sciences and neuroscientists at the prestigious University of California, Los Angeles (UCLA), Longvida was designed particularly for enhancing curcumin’s ability to reach and protect the brain. It is backed by multiple clinical studies showing benefits such as:
- Anti-inflammatory activity
- Neuroprotection and enhanced cognitive function
- Improved cardiovascular health
- Antioxidant activity
- Improved workout recovery
This patent describes Longvida’s unique SLCP (Solid Lipid Curcumin Particle) technology which utilizes lipid (fat) particles to protect curcumin in the stomach and ensure its effective absorption. In addition, it also covers Longvida’s use for warding off Alzheimer’s and other neurodegenerative and age-related disorders such as Parkinson’s and atherosclerosis. (U.S. Patent 9192644).
Longvida Nutritional Supplement Uses
Curcumin’s versatile biological effects allow Longvida to be used in a wide range of health products. Its most prominent uses include:
Longvida is most commonly used as a standalone brain health (nootropic) supplement. Indeed, the main reason for the development of Longvida was to improve curcumin’s ability to reach the brain, because it has shown promise of fighting Alzheimer’s and other forms of neurodegeneration. So far, clinical research has shown that Longvida effectively reduces levels of beta-amyloid, a marker of Alzheimer’s. Furthermore, studies in mice show improvement of Alzheimer’s and related neurodegeneration, neuroinflammation, and memory issues.
Read more: Turmeric as a nootropic
Joint Health Supplements
One of curcumin’s most popular uses is to provide relief for arthritis and other joint and muscle-related pain. Curcumin’s arthritis benefits stem from its potent anti-inflammatory activity, and are backed by multiple clinical studies. Although Longvida hasn’t been investigated in the context of arthritis yet, it has been shown to reduce inflammation in human research.
Read more: Turmeric for joint health
Longvida has the potential to be used as a cardiovascular health & anti-diabetic ingredient thanks to several research-proven benefits:
- Increase in nitric oxide (NO) activity, which can help alleviate high blood pressure
- Improved endothelial function, which protects against age-related issues such as atherosclerosis
- Improved blood lipid (fat) levels, particularly cholesterol and triglycerides
Curcumin – and by extension Longvida – has also shown promise as a immunity system supplement. Animal & human research evidence suggests that curcumin helps with a wide range of inflammatory and autoimmune disorders, including allergies, asthma, psoriasis, ulcerative colitis, and much more. In addition, it has also been demonstrated to normalize immune function, meaning that it helps keep it the immune system from under or overperforming.
Read more: Curcumin for immunity
Last but not least, Longvida holds some potential as a post-workout supplement ingredient. Both inflammation and oxidative stress play a central role in the soreness, pain, and reduction of muscle strength that follows strenuous exercise. Moreover, a resistance exercise study showed that Longvida can enhance workout recovery by reducing markers of muscle damage.
Read more: Post-workout supplementation
Longvida Optimized Curcumin is superior to generic curcumin supplements in many ways:
- High bioavailability: The biggest problem with curcumin is that it is poorly absorbed. Longvida solves this by using patented Solid Lipid Particle technology which increases permeability, solubility, and stability, resulting in bioavailability that is as at least 65 times higher than generic curcumin extracts.
- Clinical research: Longvida is one of the only curcumin ingredients backed by numerous high-quality clinical trials, which report cardiovascular, cognitive, antioxidant, and other benefits. Most of these studies are are randomized, controlled trials (RCTs) – the gold standard of human research.
- Brain-friendly: Longvida was designed particularly for enhancing curcumin’s ability to cross the blood-brain barrier, strengthening its brain-protective effects.
- Long-lasting: Longvida has a half-life of 7 hours, which means it can be effectively used even with a single daily dose. By contrast, generic extracts raise curcumin levels for only a few hours.
- Safety: Longvida is Generally Recognized as Safe (GRAS) by the FDA and has been demonstrated to be safe in animal and human studies.
- Reputation: Longvida is a highly-regarded ingredient because it was developed through a decade-long collaborative effort between neuroscientists at UCLA and researchers at Verdure Sciences, which included the testing of close to 200 different formulations.
Clinical studies of Longvida report multiple health benefits, including reduction of inflammation, and improved exercise recovery, antioxidant activity, cardiovascular health, and brain function.
This placebo-controlled study explored the effects of Longvida on vascular endothelial function, a measure of cardiovascular health that is particularly linked to atherosclerosis and diabetes. Twenty-nine adults aged 45-74 were given placebo or Longvida curcumin (2000 mg) daily for 12 weeks. Endothelial function was measured by endothelium-dependent dilation (EDD). Curcumin supplementation improved several markers of EDD, alongside increased effectiveness of nitric oxide (NO) – a key vasodilator (compound that widens blood vessels).
- The researchers concluded that “…curcumin supplementation improves EDD in MA/O adults…” 1
This randomized, double-blind, placebo-controlled study examined the effects of Longvida’s solid lipid formulation (SLCP) on brain function. A total of 60 older adults (aged 60-85) took placebo or SLCP (400 mg) in three different regimens – acute (single dose), chronic (4 weeks), or acute-on-chronic (single dose after chronic supplementation). The acute dose resulted in improved attention & working memory; chronic supplementation improved working memory and mood; and the acute-on-chronic treatment improved alertness and contentedness. In addition to these cognitive effects, curcumin was also associated with reduced total and LDL cholesterol levels.
- The researchers concluded that “…even at the low dose implemented here (approximately 80 mg) curcumin has the potential to improve important cognitive functions.” 2
This placebo-controlled study looked at the benefits of Longvida’s lipid formulation in 38 healthy adults. They were given Longvida curcumin (400 mg) or placebo daily for 4 weeks and had their blood and saliva examined. The curcumin group experienced lower blood triglyceride levels, improved salivary antioxidant capacity, lower blood beta amyloid levels (marker of Alzheimer’s), and improved markers of inflammation, immunity, and cardiovascular health.
- The researchers concluded that “…a low dose of a curcumin-lipid preparation can produce a variety of potentially health promoting effects in healthy middle aged people.” 3
This randomized, placebo-controlled study examined the benefits of Longvida for exercise-induced muscle damage (EIMD) and delayed onset muscle soreness (DOMS). A total of 28 people were given placebo or Longvida curcumin (400 mg) daily for 2 days before and 4 days after working out. The curcumin group experienced reduction in creatine kinase (CK, – 48%), a marker of muscle damage, and two cytokine markers of inflammation – TNF-α (- 25%), and IL-8 (- 21%). Although these effects were not accompanied by a reduction in reported muscle soreness, they may result in improved recovery from exercise.
- The researchers concluded that “These findings support the use of oral curcumin supplementation to reduce the symptoms of EIMD.” 4
This double-blind, randomized, placebo-controlled study looked at Longvida’s benefits for endothelial function, a measure of cardiovascular health. Thirty-nine participants (aged 45-74) were given placebo or Longvida curcumin (2000 mg) daily for 12 weeks. Curcumin supplementation improved markers of endothelial function by improving bioavailability of nitric oxide and reducing oxidative stress.
- The researchers concluded that “…curcumin supplementation is well tolerated, and improves resistance and conduit artery endothelial function.” 5
- Most research studies use 400 mg Longvida dosages, but 2000 mg has been used for cardiovascular concerns
- Longvida as a standalone supplement is usually presented in 400-500 mg doses taken 1-2 times daily
Supplements in Review Recommendation
- Longvida®, 400-2000 mg.
We recommend Longvida as a high-quality form of curcumin. Longvida not only solves curcumin’s absorption issues, but is also backed by multiple, high-quality human studies. We especially recommend it for brain-related uses because of its superior brain bioavailability.
Research suggests 400-2000 mg dosages. The 400 mg dosage seems to be sufficient for reaping Longvida’s health benefits, and can be further increased to 1000 and 2000 mg, especially for supporting cardiovascular health.
- J. R. Santos-Parker et al. BIOMARKERS OF AGING AND AGE-ASSOCIATED DISEASECURCUMIN SUPPLEMENTATION IMPROVES VASCULAR ENDOTHELIAL FUNCTION IN MIDDLE-AGED AND OLDER ADULTS. The Gerontologist, Volume 55, Issue Suppl_2, 1 November 2015, Pages 195. ↩
- Cox KH et al. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015 May;29(5):642-51. ↩
- DiSilvestro RA et al. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79. ↩
- McFarlin BK et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin. 2016 Feb 18;5:72-8. ↩
- Santos-Parker JR et al. Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress. Aging (Albany NY). 2017 Jan 3;9(1):187-208. ↩