EVNol®

Palm oil extract EVNol® has clinical backing for promoting brain, cardiovascular, skin, and liver health.

EVNol is a patented palm oil extract that offers a wide range of health benefits, including for the brain, heart, skin, and liver. This review covers its advantages over similar supplements, including the following:

• Patented. EVNol hold exclusive rights to a proprietary method for extracting antioxidants, referred to as tocotrienols, from crude palm oil.
• Certified. EVNol meets practically every safety certification available for supplements.
• Clinically researched. Many large-scale, randomized, and controlled clinical studies have corroborated its various health benefits.

Overview

EVNol, formerly known as Tocomin SupraBio, is a branded supplement that resembles vitamin E and is primarily composed of a tocotrienol complex (a combination of alpha, beta, gamma, and delta tocotrienols) extracted from fresh, virgin red palm oil. In addition to the tocotrienol complex, EVNol contains tocopherol, phytosterols, squalene, coenzyme Q10 (CoQ10), and various carotenoids that amplify its benefits. ExcelVite, formerly Carotech, is a Malaysia-based company that invented EVNol and remains its primary manufacturer.

Tocotrienols are present in barley, palm oil, and rice bran oil, and are also available as synthetic ingredients. Their popularity stems from their use in vitamin e supplements, which usually incorporate a mixture of tocotrienols with tocopherols. As one of the main components of the vitamin, tocotrienols are potent antioxidants that may facilitate fundamental metabolic processes and support healthy vision.

The tocotrienols of EVNol are extracted from crude palm oil via a proprietary process that offers markedly enhanced absorption compared with other tocotrienol extracts, which are often sourced from palm fatty acids or rice fatty acids. When taken regularly, EVNol has demonstrated a capacity to promote a variety of health benefits, from improving cardiovascular, brain, and liver well-being to fortifying the immune system.

How EVNol Works

As a fat-soluble ingredient, tocotrienols require a certain quantity of dietary fat for it to be absorbed by the body. EVNol is made up of a combination of oil and surfactant that allows the supplement to self-emulsify in the gastrointestinal tract — ultimately enabling absorption into the bloodstream, without the need for additional dietary fat intake or release during bile secretion.

EVNol Patents

EVNol preparation

ExcelVite has developed a technique that uses an “ultrahigh vacuum” and extremely low temperatures to extract tocotrienols and carotenoids from crude palm oil. This molecular distillation process is covered under U.S. Patent 5157132 A.

The formulation of the various EVNol constituents into a self-emulsifying medium for enhanced absorption is also protected by U.S. Patent 6596306 B1.

More recently, a method specifically for isolating alpha-tocotrienol has been granted protection under U.S. Patent 8106223 B2, and another process for improving this extraction has been filed under WO 2012154613 A1.

Hair growth

A special formula containing EVNol has been shown to promote hair growth and reducing hair loss in mammals (U.S. Patent 7211274 B2).

EVNol Nutritional Supplement Uses

As a natural supplement, EVNol is safely used for a number of different health-related purposes.

Nootropic Supplements

EVNol is capable of crossing the blood-brain barrier and imparting its powerful antioxidant effects on the brain, and thus, support fundamental brain functions. Moreover, tocotrienols have been shown to enhance cognitive function and mitigate the growth of brain lesions, similar to many nootropics.

Cardiovascular Supplements

One of the most common medical applications of EVNol is to improve cardiovascular health by lowering cholesterol, triglyceride, and cytokine levels.

Liver Supplements

Like artichoke and other liver supplements, EVNol may facilitate liver function and combat against related complications such as fatty liver.

Immune Supplements

Tocotrienols may have an impact on strengthening the immune response, especially for combating certain toxins such as tetanus.

Skin Supplements

A popular use of EVNol is for promoting skin and hair growth. Research has verified its ability to bolster hair growth in humans and animals.

Vision Supplements

EVNol’s high content of beta-carotene may indirectly support vision via its conversion into vitamin A.

EVNol Research

Human Research

Numerous clinical trials have shown that EVNol supplementation is associated with an eclectic array of potential health benefits. Just a selection of these studies are detailed below.

EVNol (400 mg) may mitigate growth of brain lesions

In this double-blinded, randomized, placebo-controlled study, 121 adults with white matter lesions (WMLs) in the brain took either a placebo or 200 mg of EVNol (T3) twice a day for 2-year period. Whereas the volume of the brain lesions increased in the placebo group, it remained essentially unchanged for the EVNol group. The difference in volume change was statistically significant at the end of 2 years.

• The researchers concluded that “T3 could attenuate the progression of WMLs … they can be used as a long-term supplement that may help to minimize injury of brain tissues particularly in the white matter region during an ischemic event.”¹

EVNol (300 mg) may help cholesterol levels

In this double-blinded, randomized, placebo-controlled investigation, 32 people with high cholesterol levels took 300 mg of either a soya bean placebo or EVNol every day for 6 months. Compared with the placebo group, the EVNol group had a 22-fold increase in tocotrienol levels that led to statistically significant decreases in “bad” cholesterol, or low-density lipoprotein (LDL) cholesterol. Total cholesterol fell by more than 10% and LDL cholesterol dropped by more than 17% in the EVNol group, whereas these levels stayed roughly the same for the placebo group.

• The researchers concluded that “lowering of the total and LDL cholesterol levels in hypercholesterolemic subjects could be achieved through supplementation with mixed tocotrienols.”²

EVNol (400 mg) may protect the liver of patients with a common liver disease

In this randomized, placebo-controlled investigation, 87 patients with nonalcoholic fatty liver disease (NAFLD) took either a placebo or 200 mg of EVNol twice a day for 1 year. The liver’s ability to normalize the disease was significantly better for the EVNol group than the placebo group; and the EVNol group had a statistically significant increase in disease remission compared with the placebo group. There were 2 cases of worsening diseases in the placebo group, but none in the Tocomin group.

• The researchers concluded that “this is the first clinical trial that showed the hepatoprotective effects of mixed palm tocotrienols in hypercholesterolemic adults with NAFLD.”³

EVNol (100 mg) may increase hair count in people dealing with hair loss

In this randomized, placebo-controlled investigation, 38 people with alopecia took either a placebo or 2 servings of a 50 mg EVNol capsule every day for 8 months. The number of hairs on a predetermined area of the scalp had a statistically significant increase in the EVNol group (34.5%) compared with the placebo group (-0.1%).

• The researchers concluded that “supplementation with tocotrienol capsules increases hair number in volunteers suffering from hair loss.”⁴

EVNol (400 mg) may stimulate the immune system

In this double-blinded, randomized, placebo-controlled investigation, 108 women took either a placebo or 400 mg of EVNol (TRF) per day during a 2-month period. Blood samples of the participants revealed that EVNol significantly increased the production of immune molecules — including interferon-γ and interleukin-4 (IL-4) — compared with the placebo.

• The researchers concluded that “TRF has immunostimulatory effects and potential clinical benefits to enhance immune response to vaccines.”⁵

EVNol Dosage

• Successful clinical trials have used from 100 – 400 mg of EVNol per day.
• EVNol supplements are available as softgels or capsules with a wide range of daily serving sizes, from 50 – 1200 mg. They typically include 25.32% tocotrienols and 6.90% alpha-tocopherol.